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Table 1 Baseline data of the study population overall and per site

From: Chloroquine efficacy for Plasmodium vivax malaria treatment in southern Ethiopia

Variable Shele Guba Batu Shone Overall p valuea
Total number of patients 89 52 57 90 288  
Gender male (%) 58 (65.2 %) 30 (57.7 %) 23 (40.3 %) 51 (56.7 %) 162 (56.3 %) 0.032
Age
 Median age [IQR] in years 10 [4–18] 12 [4.5–22.5] 12 [6–20] 6 [4–9] 8 [4–18] 0.0022
  ≤5 year 31 (34.8 %) 16 (30.8 %) 13 (22.8 %) 43 (47.8 %) 103 (35.8 %)  
  5 to ≤15 years 26 (29.2 %) 18 (34.6 %) 24 (42.1 %) 33 (36.7 %) 101 (35.1 %)  
  >15 years 32 (35.9 %) 18 (34.6 %) 20 (35.1 %) 14 (15.6 %) 84 (29.2 %)  
Body weight
 Median weight [IQR] in kg 22.5 [14–50] 26.5 [15–44] 35 [16.3–50.1] 20 [17–26] 22 [16–45] 0.24
 Median mg/kg [IQR] total dose of chloroquine 27.3 [25–30] 27.0 [25–30] 26.7 [23.6–28.8] 31.25 [26.98–37.5] 27.9 [25–30.8] 0.0001
Enrolment clinical parameters
 Mean (SD) temperature °C 37.5 (0.82) 37.6 (1.18) 37.0 (0.74) 37.0 (0.68) 37.3 (0.88) 0.0003
 Fever (temp >37.5 °C) N (%) 44 (49.4 %) 20 (38.5 %) 18 (31.6 %) 25 (27.8 %) 107 (37.2 %) 0.019
 Geometric mean parasitaemia µl−1 [95 % CI] 3112 [1483–3899] 6527 [4709–9046] 1961 [1661–2314] 1751 [1417–2164] 2712 [2387–3082] 0.0001
 Gametocyte carriage N (%) 86 (96.7 %) 22 (42.3 %) 5 (8.8 %) 61 (67.8 %) 174 (60.4 %) 0.000
 Geometric mean gametocyte density µl−1 [95 % CI] 334 [257–435] 99 [66–148.5] 146 [60–355.1] 26 [20.2–34] 114 [90.3–145.8] 0.000
 Mean haemoglobin (SD)b 10.6 (1.9) 12.1 (1.5) 13.8 (1.7) 14.0 (1.3) 12.5 (2.2) 0.0001
 Anaemic (Hb < 10 g/dL) N (%)b 44 (49.4 %) 5 (9.8 %) 2 (3.6 %) 0 51 (18.5 %) 0.000
  1. aDifference between sites
  2. bHb not recorded in 13 patients