Table 1 Baseline data of the study population overall and per site
From: Chloroquine efficacy for Plasmodium vivax malaria treatment in southern Ethiopia
Variable | Shele | Guba | Batu | Shone | Overall | p valuea |
|---|---|---|---|---|---|---|
Total number of patients | 89 | 52 | 57 | 90 | 288 | |
Gender male (%) | 58 (65.2 %) | 30 (57.7 %) | 23 (40.3 %) | 51 (56.7 %) | 162 (56.3 %) | 0.032 |
Age | ||||||
Median age [IQR] in years | 10 [4–18] | 12 [4.5–22.5] | 12 [6–20] | 6 [4–9] | 8 [4–18] | 0.0022 |
≤5 year | 31 (34.8 %) | 16 (30.8 %) | 13 (22.8 %) | 43 (47.8 %) | 103 (35.8 %) | |
5 to ≤15 years | 26 (29.2 %) | 18 (34.6 %) | 24 (42.1 %) | 33 (36.7 %) | 101 (35.1 %) | |
>15 years | 32 (35.9 %) | 18 (34.6 %) | 20 (35.1 %) | 14 (15.6 %) | 84 (29.2 %) | |
Body weight | ||||||
Median weight [IQR] in kg | 22.5 [14–50] | 26.5 [15–44] | 35 [16.3–50.1] | 20 [17–26] | 22 [16–45] | 0.24 |
Median mg/kg [IQR] total dose of chloroquine | 27.3 [25–30] | 27.0 [25–30] | 26.7 [23.6–28.8] | 31.25 [26.98–37.5] | 27.9 [25–30.8] | 0.0001 |
Enrolment clinical parameters | ||||||
Mean (SD) temperature °C | 37.5 (0.82) | 37.6 (1.18) | 37.0 (0.74) | 37.0 (0.68) | 37.3 (0.88) | 0.0003 |
Fever (temp >37.5 °C) N (%) | 44 (49.4 %) | 20 (38.5 %) | 18 (31.6 %) | 25 (27.8 %) | 107 (37.2 %) | 0.019 |
Geometric mean parasitaemia µl−1 [95 % CI] | 3112 [1483–3899] | 6527 [4709–9046] | 1961 [1661–2314] | 1751 [1417–2164] | 2712 [2387–3082] | 0.0001 |
Gametocyte carriage N (%) | 86 (96.7 %) | 22 (42.3 %) | 5 (8.8 %) | 61 (67.8 %) | 174 (60.4 %) | 0.000 |
Geometric mean gametocyte density µl−1 [95 % CI] | 334 [257–435] | 99 [66–148.5] | 146 [60–355.1] | 26 [20.2–34] | 114 [90.3–145.8] | 0.000 |
Mean haemoglobin (SD)b | 10.6 (1.9) | 12.1 (1.5) | 13.8 (1.7) | 14.0 (1.3) | 12.5 (2.2) | 0.0001 |
Anaemic (Hb < 10 g/dL) N (%)b | 44 (49.4 %) | 5 (9.8 %) | 2 (3.6 %) | 0 | 51 (18.5 %) | 0.000 |