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Fig. 1 | Malaria Journal

Fig. 1

From: Heterogeneous alleles comprising G6PD deficiency trait in West Africa exert contrasting effects on two major clinical presentations of severe malaria

Fig. 1

G6PD trait association tests—estimated odds ratios. Results from association tests using a composite G6PD genotype to infer G6PD deficiency trait status, where composite genotype is the total number of variant alleles present across all three deficiency SNPs (A968G, T542A, and C202T) in an individual (‘G6PD trait’). Presence or absence of full expression of the trait (i.e. full G6PD enzyme deficiency) was also tested, where presence of the ‘full’ expression of the trait required presence of one (male hemizygotes) or two (female homozygotes) deficiency alleles in total across the three loci (‘G6PD trait [full]’). Also shown are association test results for HbS (red). Estimated OR with 95 % CI is shown for association with severe malaria overall (ALL), as well as for each subphenotype (SMA, CM)

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Malaria Journal

ISSN: 1475-2875

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