Heterogeneous alleles comprising G6PD deficiency trait in West Africa exert contrasting effects on two major clinical presentations of severe malaria

Table 3 Tests of association for G6PD deficiency SNPs

	Frequency		ALL		SMA		CM
	Control	Case (SMA, CM)	OR (95 % CI)	P value	OR (95 % CI)	P value	OR (95 % CI)	P value
	N = 3836	N = 2379 (556, 890)	OR (95 % CI)	P value	OR (95 % CI)	P value	OR (95 % CI)	P value
HbS	0.072	0.013 (0.010, 0.007)	0.16 (0.12–0.21)	1.1e−38	0.16 (0.09–0.29)	2.9e−09	0.11 (0.06–0.19)	8.0e−15
A968G	0.066	0.054 (0.077, 0.048)	0.84 (0.74–0.96)	0.0102	1.09 (0.88–1.35)	0.4212	0.73 (0.58–0.91)	0.0060
T542A	0.012	0.007 (0.014, 0.005)	0.74 (0.53–1.03)	0.0706	1.36 (0.87–2.11)	0.1727	0.47 (0.23–0.99)	0.0483
C202T	0.032	0.023 (0.031, 0.021)	0.85 (0.70–1.03)	0.0906	1.09 (0.79–1.49)	0.6065	0.82 (0.60–1.11)	0.1970
G6PD_trait	0.113	0.085 (0.130, 0.078)	0.83 (0.75–0.92)	0.0006	1.14 (0.96–1.36)	0.1401	0.73 (0.61–0.87)	0.0005
G6PD_trait (full)	0.063	0.050 (0.084, 0.047)	0.80 (0.63–1.01)	0.0661	1.43 (0.99–2.08)	0.0557	0.68 (0.46–1.00)	0.0524

ISSN: 1475-2875