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Table 4 Gender-stratified tests of association

From: Heterogeneous alleles comprising G6PD deficiency trait in West Africa exert contrasting effects on two major clinical presentations of severe malaria

Male (hemizygotes)

Frequency

ALL

SMA

CM

Control

Case (SMA, CM)

OR (95 % CI)

P value

OR (95 % CI)

P value

OR (95 % CI)

P value

N = 1941

N = 1301 (309, 478)

A968G

0.073

0.050 (0.084, 0.046)

0.70 (0.51–0.95)

0.0235

1.19 (0.72–1.95)

0.4961

0.62 (0.37–1.05)

0.0772

T542A

0.011

0.009 (0.026, 0.003)

0.84 (0.40–1.80)

0.6625

2.55 (1.00–6.52)

0.0505

0.28 (0.04–2.11)

0.2167

C202T

0.032

0.026 (0.042, 0.028)

0.87 (0.56–1.34)

0.5256

1.36 (0.68–2.72)

0.3834

0.94 (0.49–1.83)

0.8628

G6PD trait

0.118

0.087 (0.155, 0.079)

0.75 (0.58–0.96)

0.0231

1.41 (0.96–2.08)

0.0832

0.67 (0.45–1.02)

0.0608

Female (heterozygotes)

Frequency

ALL

SMA

CM

Control

Case (SMA, CM)

OR (95 % CI)

P value

OR (95 % CI)

P value

OR (95 % CI)

P value

N = 1895

N = 1078 (247, 412)

A968G

0.120

0.112 (0.148, 0.086)

0.87 (0.68–1.11)

0.2656

1.14 (0.74–1.76)

0.5654

0.63 (0.42–0.95)

0.0285

T542A

0.026

0.012 (0.022, 0.012)

0.43 (0.23–0.80)

0.0084

0.71 (0.25–2.03)

0.5244

0.41 (0.15–1.16)

0.0942

C202T

0.063

0.039 (0.048, 0.029)

0.67 (0.46–0.97)

0.0355

0.83 (0.41–1.69)

0.6065

0.49 (0.25–0.95)

0.0345

G6PD trait

0.202

0.160 (0.212, 0.124)

0.74 (0.60–0.91)

0.0045

0.99 (0.68–1.45)

0.9776

0.54 (0.38–0.77)

0.0006