Pharmacokinetics of mefloquine and its effect on sulfamethoxazole and trimethoprim steady-state blood levels in intermittent preventive treatment (IPTp) of pregnant HIV-infected women in Kenya

Table 2 Comparison of pharmacokinetic parameters for mefloquine

Reference	Matrix	Subject description	Dose (mg)	C_max (ng/ml)	t_1/2 (days)	Vd (l/kg)	CL (l/h/kg)	AUC_0→∞ (µg-h/ml)
Present study	Whole blood	Pregnant	15 mg/kg	974	12.0	14.4	0.035	431
Ramharter et al. (pers comm)	Whole blood	Pregnant	15 mg/kg	577^a	16.8	30.4^b	0.073^b	308^a
Desjardins et al. [21]	Whole blood	Males	1000	800	13.8	13.3	0.066	648
Schwartz et al. [23]	Plasma	African males	1000	954	20.0	14.8	0.020	–
Schwartz et al. [23]	Plasma	Caucasian males	1000	990	27.5	20.3	0.025
De Souza et al. [26]	Plasma	Males	1000		21.6	23.2	0.031	587
Na Bangchang et al. [10]	Whole blood	Pregnant (P. falciparum)	15 mg/kg	1257	7.2	10.8	0.047	319
Na Bangchang et al. [10]	Whole blood	Non-pregnant Females (P. falciparum)	15 mg/kg	1617	8.1	10.0	0.043	349
Nosten et al. [9]	Whole blood	Pregnant	250 mg/week	–	11.6	–	0.047	–
Nosten et al. [9]	Whole blood	Pregnant	125 mg/week

^aOriginal values converted from moles to grams using the molar mass for mefloquine HCl (414.8 g/mole) for comparison
^bOriginal values divided by mean weight (58.3 kg) of the study subjects for comparison

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