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Table 2 Time to adaptation of ‘Day 0 cryopreserved blood’ with Plasmodium falciparum parasites thawed as duplicate replicates and maintained under HI-plasma, 2 % HCT conditions

From: In vitro adaptation of Plasmodium falciparum reveal variations in cultivability

Culture ID

Initial parasitaemia (%)

Time to adaptation (days)

Experimenter 1

Experimenter 2

Avg.

Culture 1

Culture 2

Culture 3

Culture 4

Dd2

1.9

13

x

13

x

13.0

CA1

0.2

25

27

27

27

26.5

CA3

1.9

18

15

25

27

21.3

CA4

2.6

15

18

18

18

17.3

CA5

2.7

27

Δ

Δ

Δ

27.0

CA6

13.5

11

13

13

15

13.0

CA14

1.9

15

15

15

25

17.5

CA15

0.1

29

41

34

41

36.3

CA16

3.3

Δ

27

27

27

27.0

CA19

1.3

42

Δ

Δ

Δ

42.0

CA20

9.2

11

11

11

11

11.0

NA4

0.6

Δ

Δ

Δ

Δ

–

NA11

1.0

Δ

Δ

Δ

Δ

–

  1. Culture ID prefix CA- and NA- refer to ‘culture adapted’ and ‘non-culture adapted’, respectively
  2. Δ indicates that a culture did not pass growth tests during the 45 days of testing. Dd2 is a highly drug resistant strain of P. falciparum derived from W2, that grows exceptionally well in culture
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Malaria Journal

ISSN: 1475-2875

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