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Fig. 3 | Malaria Journal

Fig. 3

From: Localization and interactions of Plasmodium falciparum SWIB/MDM2 homologues

Fig. 3

Molecular modelling of PfMDM2 and PfSWIB. Purple and red regions denote amino acids comprising the SWIB/MDM2 domain while green regions denote flanking regions. Purple regions represent alpha helices and random coils while red regions specifically highlight the beta sheets of the structure. a Solution structure of the SWIB/MDM2 domain of Mus musculus SWI/SNF related, matrix-associated, actin-dependent regulator of chromatin subfamily D member 1 protein (1UHR); b Solution structure of the Arabidopsis thaliana SWIB/MDM2 domain of the hypothetical protein At5g14170 (1V31); c Crystal structure of the Xenopus laevis SWIB/MDM2 domain of the E3 ubiquitin-protein ligase MDM2 protein (1YCQ, chain a); d Putative SWIB/MDM2 domain of yeast SNF12 modelled against 1UHR using the PHYRE2 modelling algorithm; e Putative SWIB/MDM2 domain of PfMDM2 modelled against 1YCQ using the EsyPred modelling algorithm, Qmean score 0.835, 13.7 % identity, annotated residues denote the start and end of the modelled domain, which are indicated by stars; f Putative SWIB/MDM2 domain of PfSWIB modelled simultaneously against 1UHR, 1V31 and 1V32 (solution structure of the SWIB/MDM2 domain of the hypothetical protein At5g08430 from Arabidopsis thaliana) using the PHYRE2 modelling algorithm, Qmean score 0.745, 28, 24 and 28 % identity to each template respectively, annotated residues denote the start and end of the modelled domain, which are indicated by stars. g Overlay of the modelled PfMDM2 domain (magenta) against 1YCQ (orange); h Overlay of the modelled PfSWIB domain (magenta) against 1V31 (orange)

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