Table 3 Genotype associations
Gene | Genotype | Malaria type | Parasitemia (day 0) | |||||
|---|---|---|---|---|---|---|---|---|
Uncomplicated | Complicated | OR (CI) | p | Mean | β | p | ||
TLR1 | rs5743551 | |||||||
CC | 59 (64.8) | 32 (35.2) | 1.26 (0.93–1.71) | 0.14 | 57,224 (91,846) | 0.16 | 0.042 | |
CT | 107 (58.5) | 76 (41.5) | 73,597 (142,004) | |||||
TT | 44 (53.7) | 38 (46.3) | 106,744 (190,805) | |||||
rs5743614 | ||||||||
AA (Ser/Ser) | 59 (62.8) | 35 (37.2) | 1.17 (0.86–1.59) | 0.32 | 57,116 (89,419) | 0.14 | 0.078 | |
AG (Ser/Ser) | 110 (58.5) | 78 (41.5) | 73,087 (142,004) | |||||
GG (Ser/Ser) | 41 (55.4) | 33 (44.6) | 111,539 (198,734) | |||||
rs5743618 | ||||||||
TT (Ile/Ile) | 202 (58.6) | 143 (41.5) | 1.41 (0.48–4.12) | 0.53 | 79,114 (147,719) | −0.03 | 0.91 | |
GT (Ser/Ile) | 7 (50.0) | 7 (50.0) | 55,513 (73,399) | |||||
GG (Ser/Ser) | 0 | 0 | – | |||||
TLR6 | rs3775073 | |||||||
TT (Lys/Lys) | 55 (57.9) | 40 (42.1) | 0.89 (0.66–1.18) | 0.42 | 87,461 (143,708) | 0.07 | 0.35 | |
TC (Lys/Lys) | 106 (63.1) | 62 (36.9) | 81,825 (167,173) | |||||
CC (Lys/Lys) | 49 (52.1) | 45 (47.9) | 61,273 (99,746) | |||||
rs5743808 | ||||||||
AA (Ile/Ile) | 158 (58.5) | 112 (41.5) | 0.96 (0.62–1.48) | 0.85 | 79,744 (150,930) | −0.04 | 0.74 | |
GA (Thr/Ile) | 47 (57.3) | 35 (42.7) | 73,177 (132,271) | |||||
GG (Thr/Thr) | 5 (71.4) | 2 (28.6) | 67,254 (77,658) | |||||