Table 1 Artemisinin and partner drug studies used to inform the resistance scenarios

Location

Pailin, Cambodia

Pursat, Cambodia

Oddar Meanchey Province, Cambodia

Tasanh, Cambodia

Sudan and Uganda

Reference

Leang et al. [16]

Leang et al. [16]

Spring et al. [17]

Bethell et al. [18]

Mukhtar et al. [19]^a; Priotto et al. [20]^b

Drugs given

DHA-PQP

DHA-PQP

DHA-PQP

AS

AS + SP

Percentage of treated individuals with slow parasite clearance

32.2 %

8.6 %

54 %

48.2 %

3.5^b %

Slow parasite clearance time (days)

8.91^c

6.04^c

10.26

10.86^c

5.42^c

Percentage of treated individuals that recrudesce to LCF

2.7 %

5.4 %

21 %

1.6^d %

3.9^a %

Percentage of individuals that recrudesce to LPF

10.7 %

0 %

24 %

4.8^d %

10.4^a %

Time to recrudesce (days)

26.9

25.6

27.1

24.5^e

25.3^a

Summary

Medium artemisinin and partner drug resistance

Low artemisinin and partner drug resistance

High artemisinin and partner drug resistance

High artemisinin resistance

No artemisinin resistance and high partner drug resistance