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Table 2 Blood coagulation parameters at baseline and at parasitaemia in 22 volunteers who developed parasitaemia

From: Alterations of blood coagulation in controlled human malaria infection

Parameter At baseline, Median (IQR) At peripheral blood parasitaemia, Median (IQR) p
Thrombin generation
 Peak thrombin, nM 191.5 (138.2–231.9) 225.4 (168.1–295.6) 0.026
 Lag time, min 12 (11–13) 10 (8–12) 0.001
 Peak time, min 19.8 (18.1–22.6) 18.1 (14.6–20.1) 0.003
 AUC 2836.1 (2494–3377) 2816.6 (2594–3412) 0.485
 Velocity Index 24.6 (14–20.1) 32.7 (19.5–54.6) 0.024
D-dimer, μg/ml 0.17 (0.13–0.21) 0.15 (0.12–0.22) 0.062
Prothrombin fragment 1 + 2, pmol/l 121 (102–152) 130 (95–190) 0.131
Von Willebrand factor, IU/ml 0.89 (0.63–1.07) 0.81 (0.7–1.04) 0.833
ADAMTS13 activity, % 103.5 (91.4–114.0) 99.9 (89.6–117.8) 0.987
Soluble P-selectin, ng/ml 31.1 (27.3–40.2) 33.4 (26.3–42.0) 0.306
Platelet count, G/l 246 (216–261) 247 (215–271) 0.911
  1. Paired Wilcoxon’s tests p values for differences between baseline and parasitaemia are given