Table 2 Blood coagulation parameters at baseline and at parasitaemia in 22 volunteers who developed parasitaemia
From: Alterations of blood coagulation in controlled human malaria infection
Parameter | At baseline, Median (IQR) | At peripheral blood parasitaemia, Median (IQR) | p |
|---|---|---|---|
Thrombin generation | |||
Peak thrombin, nM | 191.5 (138.2–231.9) | 225.4 (168.1–295.6) | 0.026 |
Lag time, min | 12 (11–13) | 10 (8–12) | 0.001 |
Peak time, min | 19.8 (18.1–22.6) | 18.1 (14.6–20.1) | 0.003 |
AUC | 2836.1 (2494–3377) | 2816.6 (2594–3412) | 0.485 |
Velocity Index | 24.6 (14–20.1) | 32.7 (19.5–54.6) | 0.024 |
D-dimer, μg/ml | 0.17 (0.13–0.21) | 0.15 (0.12–0.22) | 0.062 |
Prothrombin fragment 1 + 2, pmol/l | 121 (102–152) | 130 (95–190) | 0.131 |
Von Willebrand factor, IU/ml | 0.89 (0.63–1.07) | 0.81 (0.7–1.04) | 0.833 |
ADAMTS13 activity, % | 103.5 (91.4–114.0) | 99.9 (89.6–117.8) | 0.987 |
Soluble P-selectin, ng/ml | 31.1 (27.3–40.2) | 33.4 (26.3–42.0) | 0.306 |
Platelet count, G/l | 246 (216–261) | 247 (215–271) | 0.911 |