Therapeutic efficacy of artesunate-amodiaquine and artemether-lumefantrine combinations in the treatment of uncomplicated malaria in two ecological zones in Ghana

Table 1 Demographic, clinical, parasitological, and haematological characteristics of patients treated with AS-AQ at baseline

Characteristic	Total (n = 140)	Ecological zone		p value
Characteristic	Total (n = 140)	Forest (n = 59)	Savannah (n = 81)	p value
Male/female	74/66	29/30	45/36	0.563
Age group
<5 years	82 (58.6 %)	26 (44.1 %)	56 (69.1 %)	0.005
5–9 years	58 (41.4 %)	33 (55.9 %)	25 (30.9 %)	0.005
Axillary temperature in °C
Mean temperature (sd)^a	37.8 (0.9)	37.5 (0.1)	38.1 (1.1)	0.000
Range (min, max)	35.2, 40.0	36.9, 37.5	35.2, 40.0	0.000
Parasitaemia/µl
Geometric mean	32,479	44,669	25,750	0.001
Range (min, max)	(1000, 228,040)	(1000, 228,040)	(1029, 170,840)	0.001
Haemoglobin level in g/dl
Mean (sd)^a	8.7 (1.6)	8.7 (1.0)	8.7 (1.9)	1.000
Range (min, max)	(5.4, 13.9)	(6.0, 13.9)	(5.4, 13.9)	1.000
Previous anti-malarial intake	12 (8.6 %)	0	12 (14.8 %)^b	0.005

^aStandard deviation
^bSix children had taken AS-AQ and the other six had taken AL within the 14-day period preceding their visit to the clinic

ISSN: 1475-2875