Distribution of FcγR gene polymorphisms among two sympatric populations in Mali: differing allele frequencies, associations with malariometric indices and implications for genetic susceptibility to malaria

Table 5 Association of SNPs with antibody levels

SNP (gene)	Alleles		Comparison	Antibody responses (Mean Log 10)
				Fulani			Dogon			Fulani + Dogon
				IgG	IgG1	IgG3	IgG	IgG1	IgG3	IgG	IgG1	IgG3
(FcγRIIB (rs1050519)	Ref	G	GG vs TT/GT	9.267	29.79	0.429	5.49	8.897	0.33	5.76	10.39	0.3475
(FcγRIIB (rs1050519)	Alt	T	GG vs TT/GT	10.86	37.08	0.30	3.95	11.90	0.34	5.16	14.03	0.33
p Value				0.795	0.908	0.105	0.301	0.317	0.755	0.956	0.251	0.439
FCγRIIC (rs3933769)	Ref	C	CC vs TT/CT	14.61	44.31	0.33	5.35	10.21	0.35	5.71	11.31	0.34
FCγRIIC (rs3933769)	Alt	T	CC vs TT/CT	7.74	28.76	0.35	4.63	7.35	0.33	5.81	10.45	0.34
p Value				0.367	0.392	0.594	0.311	0.706	0.790	0.872	0.670	0.933
FCγRIIIA (rs36991)	Ref	A	AA vs GG/AG	9.83	12.27	0.35	5.09	6.66	0.32	5.74	8.31	0.34
FCγRIIIA (rs36991)	Alt	G	AA vs GG/AG	11.29	54	0.32	5.33	13.06	0.35	5.94	18.56	0.35
p Value				0.898	0.127	0.314	0.839	0.082	0.015*	0.712	0.023*	0.158

ISSN: 1475-2875