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Fig. 7 | Malaria Journal

Fig. 7

From: Prioritization of anti-malarial hits from nature: chemo-informatic profiling of natural products with in vitro antiplasmodial activities and currently registered anti-malarial drugs

Fig. 7

Self-organizing map depicting structural-activity landscape of the natural products with in vitro antiplasmodial activities. The SOM was generated based on a measure of structural and activity similarities among the NAA. Markers connected by lines represent similar compounds. Markers are coloured by activities (IC50). Connected markers that have different colours (e.g., cluster marked B) represent structurally similar compounds with different in vitro antiplasmodial activities (activity cliff). The cluster marked A, which consists of structurally similar compounds with similar in vitro antiplasmodial activities represent smooth region

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