The risk of malaria in Ghanaian infants born to women managed in pregnancy with intermittent screening and treatment for malaria or intermittent preventive treatment with sulfadoxine/pyrimethamine

Table 4 Prevalence of Plasmodium falciparum parasitaemia and anaemia at preplanned surveys at 6 and 12 months of age

Analysis population, Intervention group	No. ever had P. falciparum infection	No. children	Risk	Risk ratio^a (95 % CI)	p value*
Risk of P. falciparum infection at 6 months of age
ATP1, IPTp-SP	25	379	0.066	(Reference)	–
ATP1, ISTp-AL	28	376	0.074	1.16 (0.69, 1.95)	0.56

Analysis population, Intervention group	No. ever had P. falciparum infection	No. children	Risk	Risk ratio^a (95 % CI)	p value*
Risk of P. falciparum infection at 12 months of age
ATP1, IPTp-SP	38	402	0.095	(Reference)	–
ATP1, ISTp-AL	44	406	0.108	1.18 (0.78, 1.78)	0.44

Analysis population, Intervention group	No. ever had anaemia	No. children	Risk	Risk ratio^a (95 % CI)	p value*
Risk of anaemia (<11.0 g/dL) at 6 months of age
ATP1, IPTp-SP	147	201	0.731	(Reference)	–
ATP1, ISTp-AL	138	203	0.680	0.94 (0.83, 1.07)	0.34

Analysis population, Intervention group	No. ever had anaemia	No. children	Risk	Risk ratio^a (95 % CI)	p value*
Risk of anaemia (<11.0 g/dL) at 12 months of age
ATP1, IPTp-SP	265	319	0.830	(Reference)	–
ATP1, ISTp-AL	282	333	0.847	1.02 (0.95, 1.09)	0.59

IPTp-SP intermittent preventive treatment with sulfadoxine/pyrimethamine, ISTp-AL screening with a rapid diagnostic test (RDT) and treatment with artemether–lumefantrine, ATP1 primary analysis according to protocol
* Two-sided p values
^aCovariates adjusted: for gender, socio-economic status, rural/urban residence location, irrigated area residence location, season, ITN use, age at visit, mother’s parasitaemia status on day of enrolment into the initial cohort, predelivery haemoglobin

ISSN: 1475-2875