Fig. 7

Mutations in falcipain 2A and falcipain 2B. Key domains of falcipain are shown in the top left panel. Arm and nose domains are unique in Plasmodium falcipain. Cyan stick indicates conversion mutation. Yellow stick indicates non-conversion mutation that is similar to falcipain 2A variation in W2 strain. Red stick indicates non-conversion mutation that does not originate from W2. Red stars label the location of active site. Electrostatic potential surface of falcipain 2A and falcipain 2B is shown (bottom panel). Surface potential contribution from Q414 and E412 is circled in yellow dotted line. Green dashed lines mark the active site cleft. Falcipain 2A structure, which was taken from PDB ID: 1YVB is originally from P. falciparum strain W2. Falcipain 2B is a homology model using 1YVB as a template