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Table 2 Peptide composition of the six predicted AMA1 HLA A- and B-binding peptide pools

From: Measurement of ex vivo ELISpot interferon-gamma recall responses to Plasmodium falciparum AMA1 and CSP in Ghanaian adults with natural exposure to malaria

15mer pool

HLA A01

HLA A02

HLA A03

HLA A24

HLA B07

HLA B44

Ap1

LLSAFEFTYb (B07)b (A03, B58)c GQNYWEHPYb (B27)c

KLYCVLLLSAb (A03)b (A02, A03, A30)c SAFEFTYMIb (A01)b

EFTYMINFGRb (A03)c DVYRPINEHRb, c (A03)c

LYCVLLLSAFb (B07)b

YPLHQEHTYb, c

FEFTYMINF a, c (B27)c YEYPLHQEH a, c (B27)c

Ap2

NYMGNPWTEYb (B07, B44)b (A01A24, B27)c

NLFSSIEIVb, c YMGNPWTEYMb, c (A01, B44)b (B27)c

LFSSIEIVERb, c

  

DENTLQHAYb, c (A01, B07)b

QEQNLFSSIb (B27)c IEIVERSNYb, c

Ap3

 

YMAKYDIEEVb, c (B27)c

TQYRLPSGKb, c (A34, A01A03)c

   

Ap4

TLDEMRHFY a (B07)b (A03, A01)c MRHFYKDNKY a (B27)c

LTPVATGNQYb

 

MSPMTLDEMRb (B07)b

TLDEMRHFYKb (A01)b (A01)c

QYLKDGGFAFb (A01, A02, B07, B44)c

 

TEPLMSPMTLb (B07)b

Ap6

DISFQNYTYb (B07)b (B27, B58)c

 

NSMFCFRPAKb, c (A02)b, c (A03, A01A03, A30, B27)c SFQNYTYLSKb

 

CPRKNLQNAb, c

 

Ap7

LSASDQPKQYb (A01, B27, B58)c

   

IPHVNEFPAb, c

NEFPAIDLF a, c FECNKLVFELb, c (A02, B44, B27)c

Ap8

HGKGYNWGNYb (A30, B27)c

TQKCEIFNV a (B27)c FLPTGAFKAb, c ETQKCEIFNVa, c CLINNSSYIa (B27)c

RYKSHGKGYb (A01)b (A01A03, A30, B27)c SAFLPTGAFKb, c (B07)b (B27)c

  

TETQKCEIFb

Ap9

VENNFPCSLYb (B44)b (B27, B44)c

CLINNSSYIb, c (B27)c

SLYKDEIMKb, c (B27)c (B27, A01A03)c

 

FPCSLYKDEIb

HPIEVENNFb, c

VENNFPCSLb

VENNFPCSLYb, c (A01)b (B27, B44)c

Ap10

 

EVTSNNEVVVb, c IIIASSAAVb, c

FISDDKDSLKb, c (A02)b,c RFFVCKCVERb, c

 

KPTYDKMKIIb, c

NEVVVKEEY a, c

Ap11

 

AVLATILMVb, c VLATILMVYLb, c (A01, A03)b (A30)c

VLATILMVYb (A01)c TILMVYLYKRb ILMVYLYKRKb (A02)b (A03)c

   

Ap12

TTPVLMEKPYb (B07)

 

EASFWGEEKRb (A34)c HTTPVLMEKb, c

 

RASHTTPVLb (A02, B07, B27, B58)c

 
  1. Peptides (9-10mers) representing HLA supertypes A01, A02, A03, A24, B07 and B44 were grouped into six pools. The corresponding Ap pool containing each epitope is also shown. HLA-restrictions were defined either by testing with HLA-matched subjects (Reference 16) or predicted using NetMHC. Allele groups are assigned to supertypes where known, or are listed as individual alleles. Epitopes that experimentally recalled responses from subjects either immunized with malaria vaccines or exposed to malaria transmission are shown in bold
  2. aReference [18]
  3. bPredicted by NetMHC for US subjects
  4. cPredicted by NetMHC for Ghanaian subjects