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Table 1 Correlations between biomarkers at baseline in 12 children with severe malaria

From: Endothelial activation, haemostasis and thrombosis biomarkers in Ugandan children with severe malaria participating in a clinical trial

Biomarker (units) Mean (range) Platelets Log10Ang-1 Ang-2 Log10 Ang-2 to Ang-1 ratio Syndecan-1 ApoA1 VWF antigen Total active VWF
Platelets (× 109 per L) 92 (16–255)  
Log10 Ang-1 (log10ng/mL) 0.35 (−1.10–1.29) r = 0.6248 p = 0.0399  
Ang-2 (ng/mL) 13.97 (3.86–26.71) r = −0.1494 p = 0.6612 r = −0.4730 p = 0.1204  
Log10Ang-2 to Ang-1 ratio 0.73 (−0.70 to 2.52) r = −0.5533 p = 0.0775 r = −0.9592 p < 0.0001 r = 0.6945 p = 0.0122  
Syndecan-1 (fold-normal) 7.41 (3.44–11.12) r = −0.6790 p = 0.0216 r = −0.4881 p = 0.1074 r = 0.4358 p = 0.1568 r = 0.5226 p = 0.0813  
ApoA1 (fold-normal) 0.86 (0.40–1.45) r = 0.6051 p = 0.0486 r = 0.5687 p = 0.0537 r = −0.4707 p = 0.1225 r = −0.6322 p = 0.0274 r = −0.6814 p = 0.0147  
VWF Antigen (fold-normal) 3.39 (1.72–4.67) r = 0.0310 p = 0.9280 r = −0.1336 p = 0.6789 r = 0.5071 p = 0.0924 r = 0.2691 p = 0.3977 r = 0.0942 p = 0.7709 r = −0.1729 p = 0.5911  
Total active VWF (fold-normal) 8.27 (3.01–19.19) r = −0.0091 p = 0.9787 r = −0.0631 p = 0.8455 r = −0.4849 p = 0.1100 r = −0.1118 p = 0.7293 r = −0.2046 p = 0.5236 r = 0.1813 p = 0.5729 r = 0.0868 p = 0.7885  
ADAMTS13 (fold-normal) 0.90 (0.58–1.27) r = −0.0328 p = 0.9237 r = 0.0064 p = 0.9843 r = −0.0394 p = 0.9033 r = −0.0001 p = 0.9999 r = −0.2614 p = 0.4119 r = 0.3197 p = 0.3111 r = 0.3833 p = 0.2187 r = 0.2844 p = 0.3702
  1. NB Significant correlations are indicated in italics