Table 1 Correlations between biomarkers at baseline in 12 children with severe malaria
Biomarker (units) | Mean (range) | Platelets | Log10Ang-1 | Ang-2 | Log10 Ang-2 to Ang-1 ratio | Syndecan-1 | ApoA1 | VWF antigen | Total active VWF |
|---|---|---|---|---|---|---|---|---|---|
Platelets (× 109 per L) | 92 (16–255) | ||||||||
Log10 Ang-1 (log10ng/mL) | 0.35 (−1.10–1.29) | r = 0.6248 p = 0.0399 | |||||||
Ang-2 (ng/mL) | 13.97 (3.86–26.71) | r = −0.1494 p = 0.6612 | r = −0.4730 p = 0.1204 | ||||||
Log10Ang-2 to Ang-1 ratio | 0.73 (−0.70 to 2.52) | r = −0.5533 p = 0.0775 | r = −0.9592 p < 0.0001 | r = 0.6945 p = 0.0122 | |||||
Syndecan-1 (fold-normal) | 7.41 (3.44–11.12) | r = −0.6790 p = 0.0216 | r = −0.4881 p = 0.1074 | r = 0.4358 p = 0.1568 | r = 0.5226 p = 0.0813 | ||||
ApoA1 (fold-normal) | 0.86 (0.40–1.45) | r = 0.6051 p = 0.0486 | r = 0.5687 p = 0.0537 | r = −0.4707 p = 0.1225 | r = −0.6322 p = 0.0274 | r = −0.6814 p = 0.0147 | |||
VWF Antigen (fold-normal) | 3.39 (1.72–4.67) | r = 0.0310 p = 0.9280 | r = −0.1336 p = 0.6789 | r = 0.5071 p = 0.0924 | r = 0.2691 p = 0.3977 | r = 0.0942 p = 0.7709 | r = −0.1729 p = 0.5911 | ||
Total active VWF (fold-normal) | 8.27 (3.01–19.19) | r = −0.0091 p = 0.9787 | r = −0.0631 p = 0.8455 | r = −0.4849 p = 0.1100 | r = −0.1118 p = 0.7293 | r = −0.2046 p = 0.5236 | r = 0.1813 p = 0.5729 | r = 0.0868 p = 0.7885 | |
ADAMTS13 (fold-normal) | 0.90 (0.58–1.27) | r = −0.0328 p = 0.9237 | r = 0.0064 p = 0.9843 | r = −0.0394 p = 0.9033 | r = −0.0001 p = 0.9999 | r = −0.2614 p = 0.4119 | r = 0.3197 p = 0.3111 | r = 0.3833 p = 0.2187 | r = 0.2844 p = 0.3702 |