Endothelial activation, haemostasis and thrombosis biomarkers in Ugandan children with severe malaria participating in a clinical trial

Table 1 Correlations between biomarkers at baseline in 12 children with severe malaria

Biomarker (units)	Mean (range)	Platelets	Log₁₀Ang-1	Ang-2	Log₁₀ Ang-2 to Ang-1 ratio	Syndecan-1	ApoA1	VWF antigen	Total active VWF
Platelets (× 10⁹ per L)	92 (16–255)
Log₁₀ Ang-1 (log₁₀ng/mL)	0.35 (−1.10–1.29)	r = 0.6248 p = 0.0399
Ang-2 (ng/mL)	13.97 (3.86–26.71)	r = −0.1494 p = 0.6612	r = −0.4730 p = 0.1204
Log₁₀Ang-2 to Ang-1 ratio	0.73 (−0.70 to 2.52)	r = −0.5533 p = 0.0775	r = −0.9592 p < 0.0001	r = 0.6945 p = 0.0122
Syndecan-1 (fold-normal)	7.41 (3.44–11.12)	r = −0.6790 p = 0.0216	r = −0.4881 p = 0.1074	r = 0.4358 p = 0.1568	r = 0.5226 p = 0.0813
ApoA1 (fold-normal)	0.86 (0.40–1.45)	r = 0.6051 p = 0.0486	r = 0.5687 p = 0.0537	r = −0.4707 p = 0.1225	r = −0.6322 p = 0.0274	r = −0.6814 p = 0.0147
VWF Antigen (fold-normal)	3.39 (1.72–4.67)	r = 0.0310 p = 0.9280	r = −0.1336 p = 0.6789	r = 0.5071 p = 0.0924	r = 0.2691 p = 0.3977	r = 0.0942 p = 0.7709	r = −0.1729 p = 0.5911
Total active VWF (fold-normal)	8.27 (3.01–19.19)	r = −0.0091 p = 0.9787	r = −0.0631 p = 0.8455	r = −0.4849 p = 0.1100	r = −0.1118 p = 0.7293	r = −0.2046 p = 0.5236	r = 0.1813 p = 0.5729	r = 0.0868 p = 0.7885
ADAMTS13 (fold-normal)	0.90 (0.58–1.27)	r = −0.0328 p = 0.9237	r = 0.0064 p = 0.9843	r = −0.0394 p = 0.9033	r = −0.0001 p = 0.9999	r = −0.2614 p = 0.4119	r = 0.3197 p = 0.3111	r = 0.3833 p = 0.2187	r = 0.2844 p = 0.3702

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