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Table 5 Frequency distribution of the combination pvdhfr and pvdhps from 37 P. vivax samples collected in Kalabakan and Kota Marudu, Sabah demonstrated four distinct haplotypes

From: Mutations of pvdhfr and pvdhps genes in vivax endemic-malaria areas in Kota Marudu and Kalabakan, Sabah

Pvdhfr alleles Pvdhps alleles No of isolates (%) No of dhfr/dhps combination mutant genotype
Kalabakan (n = 26) Kota Marudu (n = 11)
13Ile/33Pro/57Leu/58Arg/61Met/117Thr/173Ile 383Gly553Ala 7 (26.92) 6 (54.55) 4 dhfr, 1 dhps
13Ile/33Pro/57Leu/58Ser/61Thr/117Thr/173Ile 383Gly/553Ala 14 (53.85) 2 (18.18) 2 dhfr, 1 dhps
13Ile/33Pro/57Leu/58Arg/61Met/117Thr/173Ile 383Ala/553Ala 1 (3.85) 2 (18.18) 4 dhfr
13Ile/33Pro/57Leu/58Ser/61Thr/117Thr/173Ile 383Ala/553Ala 4 (15.38) 1 (9.09) 2 dhfr
  1. Ile isoleucine, Leu leucine, Ser serine, Thr threonine, Pro proline, Arg arginine, Met methionine, Ala alanine, Gly glycine