Table 5 Frequency distribution of the combination pvdhfr and pvdhps from 37 P. vivax samples collected in Kalabakan and Kota Marudu, Sabah demonstrated four distinct haplotypes
Pvdhfr alleles | Pvdhps alleles | No of isolates (%) | No of dhfr/dhps combination mutant genotype | |
|---|---|---|---|---|
Kalabakan (n = 26) | Kota Marudu (n = 11) | |||
13Ile/33Pro/57Leu/58Arg/61Met/117Thr/173Ile | 383Gly553Ala | 7 (26.92) | 6 (54.55) | 4 dhfr, 1 dhps |
13Ile/33Pro/57Leu/58Ser/61Thr/117Thr/173Ile | 383Gly/553Ala | 14 (53.85) | 2 (18.18) | 2 dhfr, 1 dhps |
13Ile/33Pro/57Leu/58Arg/61Met/117Thr/173Ile | 383Ala/553Ala | 1 (3.85) | 2 (18.18) | 4 dhfr |
13Ile/33Pro/57Leu/58Ser/61Thr/117Thr/173Ile | 383Ala/553Ala | 4 (15.38) | 1 (9.09) | 2 dhfr |