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Table 1 Clinical trials of azithromycin plus other drug against P. falciparum malaria

From: Macrolides and associated antibiotics based on similar mechanism of action like lincosamides in malaria

Study demographic details Regimen Efficacy ( %) d28
Year Place Reference Pop Nb Azithromycin Other Drug Route Days
Dosage/d Route Nb doses/d Druga Dosage/d Nb doses/d
1996 Thailand NaBangchang [78] A 30 500 mg PO 1 Ath 300 mg 1 PO 3/1 14.8
2001 India Dunne 2005 [3] A 64 1000 mg PO 2 C 600 mg 2 PO 3 90
2006 Thailand Noedl 2006 [41] A 27 1500 mg PO 2 A 200 mg 2 PO 3 92
    A 27 1000 mg PO 1 A 200 mg 1 PO 3 89
    A 16 1500 mg PO 2 Q 20 mg/kg 2 PO 3 73
    A 27 1500 mg PO 3 Q 30 mg/kg 3 PO 3 92
2006 Thailand Miller 2006 [44] A 10 1000 mg PO 2 Q 30 mg/kg 3 PO 3 90
    A 20 1000 mg PO 2 Q 30 mg/kg 3 PO 5 100
    A 20 1500 mg PO 3 Q 30 mg/kg 3 PO 3 100
2007 Malawi Kalilani 2007 [8] P 47 1000 mg PO 2 SP 1500/75 mg 3 PO 2 91
2008 Tanzania Sykes 2009 [9] C 129 20 mg/kg PO 1 A 4 mg/kg 1 PO 3 42
2009 Bangladesh Thriemer 2010 [43] A   1500 mg PO 1 A 200 mg 1 PO 3 95
    or 152 or     or     
    C   30 mg/kg PO 1 A 4 mg/kg 1 PO 3 95
2007–8 Malawi Laufer 2012 [10] C 160 30 mg/kg PO 1 C 10 mg/kg 1 PO 2 99
2004–6 Africa Sagara 2014 [11] A 227 1000 mg PO 1 C 600 mg 1 PO 3 99
  1. Randomized controlled trial
  2. Only trials with adequate dosing, i.e. clindamycin given at least twice daily are mentioned in this table
  3. Pop population, A adult, C children, P pregnant women
  4. a A artesunate, Ath arthemeter, C chloroquine, F fosmidomycin, Q quinine, SP sulfadoxine–pyriméthamine