Malaria Journal

Table 2 Clinical trials of clindamycin monotherapy against P. falciparum malaria

From: Macrolides and associated antibiotics based on similar mechanism of action like lincosamides in malaria

Study demographic details					Regimen
Year	Place	Reference	Pop	Nb	Dosage	Form	Nb doses/d	Route	Nb days	Efficacy (%)
1975	USA	Clyde, 1975 [50]	A	3	450 mg	Salt	3	PO	3	100
1975	Thailand	Hall, 1975 [79]	A	10	450 mg	Salt	3	PO	3	50
1981	Brazil	Alecrim, 1981 [80]	A	17	10 mg/kg	Salt	2	IV	3	65
1981	Brazil	Alecrim, 1981 [80]	A	14	10 mg/kg	Salt	2	IV + PO	7	100
1982	Brazil	Alecrim, 1982 [81]	A	26	10 mg/kg	Salt	2	IV, PO	5	100
1982	Philippines	Rivera, 1982 [82]	A	24	300 mg	Salt	2	IV + PO	7	100
1982	Philippines	Rivera, 1982 [82]	A	12	600 mg	Salt	2	IV + PO	7	100
1982	Philippines	Cabrera, 1982 [83]	A	12	10 mg/kg	Salt	2	IV + PO	7	100
1982	Philippines	Cabrera, 1982 [83]	A	19	20 mg/kg	Salt	2	IV	3	89
1984	Columbia	Restrepo, 1984 [84]	A	6	20 mg/kg	Salt	2	IV	3	100
1984	Columbia	Restrepo, 1984 [84]	A	9	10 mg/kg	Salt	2	IV + PO	7	100
1984	Columbia	Restrepo, 1984 [84]	A	5	20 mg/kg	Salt	2	IV	7	100
1984	Columbia	Restrepo, 1984 [84]	A	10	20 mg/kg	Salt	1	IV	7	100
1985	Sudan	El Wakeel, 1985 [85]	A	20	5 mg/kg	Salt	2	PO	5	90
1988	Brazil	Meira, 1988 [86]	A, C	129	10 mg/kg	Salt	2	PO, IV	5–7	97
1988	Brazil	Meira, 1988 [86]	A, C	16	10 mg/kg	Salt	1	PO, IV	5–7	50
1988	Brazil	Meira, 1988 [86]	A, C	35	2.5 mg/kg	Salt	1	PO	5	80
1989	Brazil	Kremsner, 1988 [20]	A	35	5 mg/kg	Base	2	PO	5	100
1990	Philippines	Salazar, 1990 [87]	A	31	300 mg	Salt	2	PO	5	100
1990	Philippines	Salazar, 1990 [87]	A	10	600 mg	Salt	2	PO	5	100
1993	Gabon	Salazar, 1990 [87]	A	38	5 mg/kg	Base	2	PO	5	97
1994	East Timor	Oemijati, 1994 [88]	A	30	300 mg	Salt	2	PO	5	100

A adults, C children

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ISSN: 1475-2875

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