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Table 2 Clinical trials of clindamycin monotherapy against P. falciparum malaria

From: Macrolides and associated antibiotics based on similar mechanism of action like lincosamides in malaria

Study demographic details Regimen
Year Place Reference Pop Nb Dosage Form Nb doses/d Route Nb days Efficacy (%)
1975 USA Clyde, 1975 [50] A 3 450 mg Salt 3 PO 3 100
1975 Thailand Hall, 1975 [79] A 10 450 mg Salt 3 PO 3 50
1981 Brazil Alecrim, 1981 [80] A 17 10 mg/kg Salt 2 IV 3 65
1981 Brazil Alecrim, 1981 [80] A 14 10 mg/kg Salt 2 IV + PO 7 100
1982 Brazil Alecrim, 1982 [81] A 26 10 mg/kg Salt 2 IV, PO 5 100
1982 Philippines Rivera, 1982 [82] A 24 300 mg Salt 2 IV + PO 7 100
1982 Philippines Rivera, 1982 [82] A 12 600 mg Salt 2 IV + PO 7 100
1982 Philippines Cabrera, 1982 [83] A 12 10 mg/kg Salt 2 IV + PO 7 100
1982 Philippines Cabrera, 1982 [83] A 19 20 mg/kg Salt 2 IV 3 89
1984 Columbia Restrepo, 1984 [84] A 6 20 mg/kg Salt 2 IV 3 100
1984 Columbia Restrepo, 1984 [84] A 9 10 mg/kg Salt 2 IV + PO 7 100
1984 Columbia Restrepo, 1984 [84] A 5 20 mg/kg Salt 2 IV 7 100
1984 Columbia Restrepo, 1984 [84] A 10 20 mg/kg Salt 1 IV 7 100
1985 Sudan El Wakeel, 1985 [85] A 20 5 mg/kg Salt 2 PO 5 90
1988 Brazil Meira, 1988 [86] A, C 129 10 mg/kg Salt 2 PO, IV 5–7 97
1988 Brazil Meira, 1988 [86] A, C 16 10 mg/kg Salt 1 PO, IV 5–7 50
1988 Brazil Meira, 1988 [86] A, C 35 2.5 mg/kg Salt 1 PO 5 80
1989 Brazil Kremsner, 1988 [20] A 35 5 mg/kg Base 2 PO 5 100
1990 Philippines Salazar, 1990 [87] A 31 300 mg Salt 2 PO 5 100
1990 Philippines Salazar, 1990 [87] A 10 600 mg Salt 2 PO 5 100
1993 Gabon Salazar, 1990 [87] A 38 5 mg/kg Base 2 PO 5 97
1994 East Timor Oemijati, 1994 [88] A 30 300 mg Salt 2 PO 5 100
  1. A adults, C children