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Table 2 Risk factors of soluble HLA-G evolution from 3 to 12 months in 165 newborns at Tori Bossito, 2007–2010: latent class analysis

From: Evolution of the levels of human leukocyte antigen G (HLA-G) in Beninese infant during the first year of life in a malaria endemic area: using latent class analysis

Covariates Univariate estimationa Adjusted estimationb 95 % CI p value
Intercept 0.58 0.28–0.88 <10−3*
HLA-G in cord blood
 No   
 Yes 0.60 0.42 0.15–0.70 0.002c*
Low birthweight (<2500 g)
 No   
 Yes 0.62 0.86 0.42–1.29 <10−3*
Malaria infections
 ≤1   
 >1 0.20 0.33 0.11–0.54 0.003*
Malaria exposure (quartiles)
 Low   
 Middle 0.33 0.43 0.19–0.68 0.001*
 High and very high 0.32 0.35 0.13–0.56 0.002*
Placental malaria
 No   
 Yes –0.07 –0.12 –0.35–0.11 0.36
  1. aUnivariate estimation represents the coefficient of the univariate regression
  2. bAdjusted estimation is obtained after the multivariate analysis
  3. cResults were the same, when “HLA-G in cord blood” was replaced by “HLA-G in maternal peripheral blood”. Presence of sHLA-G in maternal blood is highly significantly related to high level of HLA-G in newborns during the first 12 months. We did not introduce together the two covariates in the model because they are highly correlated [24]