|
Covariates
|
Univariate estimationa
|
Adjusted estimationb
|
95 % CI
|
p value
|
|---|
|
Intercept
|
–
|
0.58
|
0.28–0.88
|
<10−3*
|
|
HLA-G in cord blood
|
|
No
|
–
|
–
| | |
|
Yes
|
0.60
|
0.42
|
0.15–0.70
|
0.002c*
|
|
Low birthweight (<2500 g)
|
|
No
|
–
|
–
| | |
|
Yes
|
0.62
|
0.86
|
0.42–1.29
|
<10−3*
|
|
Malaria infections
|
|
≤1
|
–
|
–
| | |
|
>1
|
0.20
|
0.33
|
0.11–0.54
|
0.003*
|
|
Malaria exposure (quartiles)
|
|
Low
|
–
|
–
| | |
|
Middle
|
0.33
|
0.43
|
0.19–0.68
|
0.001*
|
|
High and very high
|
0.32
|
0.35
|
0.13–0.56
|
0.002*
|
|
Placental malaria
|
|
No
|
–
|
–
| | |
|
Yes
|
–0.07
|
–0.12
|
–0.35–0.11
|
0.36
|
-
aUnivariate estimation represents the coefficient of the univariate regression
-
bAdjusted estimation is obtained after the multivariate analysis
-
cResults were the same, when “HLA-G in cord blood” was replaced by “HLA-G in maternal peripheral blood”. Presence of sHLA-G in maternal blood is highly significantly related to high level of HLA-G in newborns during the first 12 months. We did not introduce together the two covariates in the model because they are highly correlated [24]
