Fig. 4
From: Population pharmacokinetic properties of artemisinin in healthy male Vietnamese volunteers
Box (25th and 75th percentile) and whisker (1.5 × interquartile range) plots of the full covariate models. The solid black zero-line represents no covariate effect (and the dotted black lines represent a covariate effect of ± 20 %). Formulation (a), dose (b) and the potential drug–drug interaction with piperaquine (c) were investigated as covariates. MTT is the mean transit-time, F is the relative oral bioavailability, V/F is the apparent volume of distribution and CL/F is the apparent elimination clearance. All covariates were added as categorical functions