From: Population pharmacokinetic properties of artemisinin in healthy male Vietnamese volunteers
Parameter | Population estimate (RSE %) | 95 % CI | IIV/IOV* CV % (RSE %) | 95 % CI |
---|---|---|---|---|
CL/F (L/h) | 417 (9.32) | 350-501 | 17.1* (34.3) | 11.1-22.6 |
V/F (L) | 1210 (9.02) | 1030-1450 | – | – |
Nr. trans comp | 7 fix | – | – | – |
MTT (h) | 0.787 (5.97) | 0.702-0.891 | 53.9* (20.3) | 41.6-66.9 |
F (%) | 100 (fixed) | – | 34.3 (52.3) | 17.3-50.5 |
σ (CV %) | 51.6 (5.84) | 44.9-58.1 | – | – |