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Table 2 Parameter estimates of the final model describing artemisinin population pharmacokinetics in healthy male Vietnamese subjects

From: Population pharmacokinetic properties of artemisinin in healthy male Vietnamese volunteers

Parameter

Population estimate (RSE %)

95 % CI

IIV/IOV* CV % (RSE %)

95 % CI

CL/F (L/h)

417 (9.32)

350-501

17.1* (34.3)

11.1-22.6

V/F (L)

1210 (9.02)

1030-1450

Nr. trans comp

7 fix

MTT (h)

0.787 (5.97)

0.702-0.891

53.9* (20.3)

41.6-66.9

F (%)

100 (fixed)

34.3 (52.3)

17.3-50.5

σ (CV %)

51.6 (5.84)

44.9-58.1

  1. CL/F, apparent elimination clearance; V/F, apparent volume of distribution; Nr. trans comp, number of transit compartments in the absorption model; MTT, mean transit-time of the absorption phase; F, relative oral bioavailability; σ, additive residual error. RSE is the relative standard error calculated as 100 × standard deviation/mean. CV % is the coefficient of variation calculated as \(100 \times SQRT\left( {e^{variance} - 1} \right)\) for inter-individual variability (IIV) and inter-occasion variability (IOV). 95 % CI, 95 % confidence intervals calculated as the 2.5 and 97.5 percentiles of bootstrap estimates. Parameter estimates are based on population mean values from NONMEM, RSE % and CI values are based on 954 successful bootstrap runs (out of 1000)