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Table 2 Fixed-ratio interaction of drugs against Plasmodium falciparum 3D7 strains

From: Synergistic anti-malarial action of cryptolepine and artemisinins

Drug combination ΣFIC50 Mean ΣFIC50 Interaction
4:1 3:2 2:3 1:4
Cryptolepine + artemether 0.4891 0.4727 0.3094 0.1765 0.362 Synergism
Cryptolepine + artesunate 0.8658 0.9469 0.433 0.530 0.693 Synergism
Cryptolepine + dihydroartemisinin 1.214 0.0906 0.1263 0.181 0.403 Synergism
  1. The ratios 4:1, 3:2, 2:3 and 1:4 refer to fixed dose ratios for cryptolepine to the arteminisins. Values are expressed as the means from at least three in vitro experiments