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Table 2 Fixed-ratio interaction of drugs against Plasmodium falciparum 3D7 strains

From: Synergistic anti-malarial action of cryptolepine and artemisinins

Drug combination

ΣFIC50

Mean ΣFIC50

Interaction

4:1

3:2

2:3

1:4

Cryptolepine + artemether

0.4891

0.4727

0.3094

0.1765

0.362

Synergism

Cryptolepine + artesunate

0.8658

0.9469

0.433

0.530

0.693

Synergism

Cryptolepine + dihydroartemisinin

1.214

0.0906

0.1263

0.181

0.403

Synergism

  1. The ratios 4:1, 3:2, 2:3 and 1:4 refer to fixed dose ratios for cryptolepine to the arteminisins. Values are expressed as the means from at least three in vitro experiments
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Malaria Journal

ISSN: 1475-2875

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