Table 4 Percentage suppression of P. berghei infected mice given combination treatment
From: Synergistic anti-malarial action of cryptolepine and artemisinins
Drugs | Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 |
|---|---|---|---|---|---|---|
Artesunate 6 mg/kg | 40.74 ± 10.4 | 89.87 ± 2.2 | 97.92 ± 1.3 | 90.20 ± 2.1 | 87.40 ± 6.9 | 90.44 ± 2.5 |
Cryptolepine 40 mg/kg | 53.70 ± 13.1 | 57.81 ± 4.0 | 65.3 ± 7.5 | 77.48 ± 15.2 | 82.16 ± 5.4 | 83.19 ± 6.4 |
ED50 (1:1) | 73.15 ± 9.8 | 95.78 ± 9.8 | 93.06 ± 1.39 | 68.03 ± 12.6 | 78.35 ± 9.0 | 88.53 ± 4.4 |
ED50/2 (1/2:1/2) | 80.56 ± 3.7 | 79.75 ± 5.24 | 88.89 ± 2.8 | 85.03 ± 2.7 | 90.81 ± 3.47 | 92.35 ± 2.2 |
ED50/4 (1/4:1/4) | 87.96 ± 3.1 | 96.84 ± 1.1 | 76.39 ± 6.1 | 85.03 ± 6.8 | 82.94 ± 3.5 | 84.70 ± 2.2 |
ED50/8 (1/8:1/8) | 86.11 ± 1.46 | 86.50 ± 2.5 | 77.08 ± 6.9 | 0.51 ± 14.65 | −23.0 ± 12.4 | −8.03 ± 10.3 |