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Table 4 Percentage suppression of P. berghei infected mice given combination treatment

From: Synergistic anti-malarial action of cryptolepine and artemisinins

Drugs Day 1 Day 2 Day 3 Day 4 Day 5 Day 6
Artesunate 6 mg/kg 40.74 ± 10.4 89.87 ± 2.2 97.92 ± 1.3 90.20 ± 2.1 87.40 ± 6.9 90.44 ± 2.5
Cryptolepine 40 mg/kg 53.70 ± 13.1 57.81 ± 4.0 65.3 ± 7.5 77.48 ± 15.2 82.16 ± 5.4 83.19 ± 6.4
ED50 (1:1) 73.15 ± 9.8 95.78 ± 9.8 93.06 ± 1.39 68.03 ± 12.6 78.35 ± 9.0 88.53 ± 4.4
ED50/2 (1/2:1/2) 80.56 ± 3.7 79.75 ± 5.24 88.89 ± 2.8 85.03 ± 2.7 90.81 ± 3.47 92.35 ± 2.2
ED50/4 (1/4:1/4) 87.96 ± 3.1 96.84 ± 1.1 76.39 ± 6.1 85.03 ± 6.8 82.94 ± 3.5 84.70 ± 2.2
ED50/8 (1/8:1/8) 86.11 ± 1.46 86.50 ± 2.5 77.08 ± 6.9 0.51 ± 14.65 −23.0 ± 12.4 −8.03 ± 10.3
  1. Values are expressed as Mean ± SEM from five independent experiments