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Table 6 Effects of the concomitant administration of cryptolepine and artesunate 4 mg kg−1 on the haematological indices of Sprague-Dawley rats treated for 3 days

From: Synergistic anti-malarial action of cryptolepine and artemisinins

Parameters Control Cryptolepine
25 mg kg−1 50 mg kg−1 100 mg kg−1
WBC (×103/µL) 9.83 ± 1.63 8.37 ± 1.54 13.03 ± 2.28 12.73 ± 1.04
RBC (×106/µL) 6.41 ± 0.45 6.86 ± 0.26 6.58 ± 0.24 6.47 ± 0.29
HGB (g/dL) 11.63 ± 0.93 12.07 ± 0.20 11.77 ± 0.23 11.93 ± 0.12
HCT (%) 39.27 ± 1.68 38.4 ± 1.07 37.3 ± 0.90 35.3 ± 1.15
MCV (fL) 61.7 ± 2.19 56.03 ± 0.63 56.77 ± 0.72 54.63 ± 0.68*
MCH (pg) 18.13 ± 0.69 17.67 ± 0.44 17.9 ± 0.37 18.53 ± 0.69
MCHC (g/dL) 29.43 ± 1.15 31.47 ± 0.44 31.57 ± 0.45 33.87 ± 0.83*
PLT (×103/µL) 516.33 ± 76.50 821.33 ± 9.02 725.67 ± 67.65 843.67 ± 44.67
LYMP (%) 72 ± 4.18 75.73 ± 2.80 77.38 ± 1.73 83.43 ± 2.84
  1. Cryptolepine was combined with a fixed dose of artesunate (4 mg kg−1). Values are expressed as mean ± SEM (n=5), compared to the controls (ANOVA) followed by Student‘s Newman–Keuls multiple comparison test
  2. Asterisk indicates significance (P < 0.05)