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Table 6 Effects of the concomitant administration of cryptolepine and artesunate 4 mg kg−1 on the haematological indices of Sprague-Dawley rats treated for 3 days

From: Synergistic anti-malarial action of cryptolepine and artemisinins

Parameters

Control

Cryptolepine

25 mg kg−1

50 mg kg−1

100 mg kg−1

WBC (×103/µL)

9.83 ± 1.63

8.37 ± 1.54

13.03 ± 2.28

12.73 ± 1.04

RBC (×106/µL)

6.41 ± 0.45

6.86 ± 0.26

6.58 ± 0.24

6.47 ± 0.29

HGB (g/dL)

11.63 ± 0.93

12.07 ± 0.20

11.77 ± 0.23

11.93 ± 0.12

HCT (%)

39.27 ± 1.68

38.4 ± 1.07

37.3 ± 0.90

35.3 ± 1.15

MCV (fL)

61.7 ± 2.19

56.03 ± 0.63

56.77 ± 0.72

54.63 ± 0.68*

MCH (pg)

18.13 ± 0.69

17.67 ± 0.44

17.9 ± 0.37

18.53 ± 0.69

MCHC (g/dL)

29.43 ± 1.15

31.47 ± 0.44

31.57 ± 0.45

33.87 ± 0.83*

PLT (×103/µL)

516.33 ± 76.50

821.33 ± 9.02

725.67 ± 67.65

843.67 ± 44.67

LYMP (%)

72 ± 4.18

75.73 ± 2.80

77.38 ± 1.73

83.43 ± 2.84

  1. Cryptolepine was combined with a fixed dose of artesunate (4 mg kg−1). Values are expressed as mean ± SEM (n=5), compared to the controls (ANOVA) followed by Student‘s Newman–Keuls multiple comparison test
  2. Asterisk indicates significance (P < 0.05)