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Fig. 3 | Malaria Journal

Fig. 3

From: Tafenoquine treatment of Plasmodium vivax malaria: suggestive evidence that CYP2D6 reduced metabolism is not associated with relapse in the Phase 2b DETECTIVE trial

Fig. 3

Summary of TQ-related components detected in incubations of TQ with recombinant human CYP Supersomes. TQ-related compounds detected in 5 and 10 μM incubations of TQ with recombinant human CYP enzymes (Supersomes™), hepatocytes and appropriate controls (retention time and protonated molecular ion observed by UPLC-MS in parenthesis). The Carboxy-TQ derivative observed after prolonged incubation is circled

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Malaria Journal

ISSN: 1475-2875

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