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Table 1 Clinical outcome and country by treatment in 199 subjects involved in the CYP2D6 PGx analysis

From: Tafenoquine treatment of Plasmodium vivax malaria: suggestive evidence that CYP2D6 reduced metabolism is not associated with relapse in the Phase 2b DETECTIVE trial

 

TQ plus CQ (n = 134, total)

PQ plus CQ (n = 31)

CQ plus placebo (n = 34)

50 mg (n = 34)

100 mg (n = 35)

300 mg (n = 37)

600 mg (n = 28)

N, subjects (%) per treatment arm

Clinical outcome

 6 month relapse-free (n = 126)

18 (53)

17 (49)

32 (86)

26 (93)

23 (74)

10 (29)

 Relapsed (n = 73)

16 (47)

18 (51)

5 (14)

2 (7)

8 (26)

24 (71)

Country

 India (n = 3)

1 (3)

1 (3)

1 (3)

0 (0)

0 (0)

0 (0)

 Peru (n = 114)

20 (59)

21 (60)

19 (51)

16 (57)

18 (58)

20 (59)

 Thailand (n = 82)

13 (38)

13 (37)

17 (46)

12 (43)

13 (42)

14 (41)