|
CYP2D6 genotype
|
CYP2D6 metabolizer phenotypea
|
CYP2D6 activity scoreb
|
All subjects n = 199 N (%)
|
India n = 3 N (%)
|
Peru n = 114 N (%)
|
Thailand n = 82 N (%)
|
|---|
|
*4/*4
|
PM
|
0
|
1 (0.5)
|
–
|
1 (0.9)
|
–
|
|
*4/*41
|
IM
|
0.5
|
1 (0.5)
|
–
|
1 (0.9)
|
–
|
|
*1/*4
|
IM
|
1.0
|
11 (5.5)
|
–
|
8 (7.0)
|
3 (3.7)
|
|
*10/*10
|
IM
|
1.0
|
19 (9.5)
|
–
|
–
|
19 (23.2)
|
|
*10/*41
|
IM
|
1.0
|
2 (1)
|
–
|
–
|
2 (2.4)
|
|
*2/*4
|
IM
|
1.0
|
3 (1.5)
|
–
|
3 (2.6)
|
–
|
|
*41/*41
|
IM
|
1.0
|
2 (1)
|
–
|
–
|
2 (2.4)
|
|
*1/*10
|
EM
|
1.5
|
15 (7.5)
|
–
|
–
|
15 (18.3)
|
|
*1/*41
|
EM
|
1.5
|
6 (3)
|
–
|
3 (2.6)
|
3 (3.7)
|
|
*1/*9
|
EM
|
1.5
|
2 (1)
|
–
|
2 (1.8)
|
–
|
|
*2/*10
|
EM
|
1.5
|
14 (7)
|
–
|
–
|
14 (17.1)
|
|
*2/*41
|
EM
|
1.5
|
4 (2)
|
–
|
–
|
4 (4.9)
|
|
*1/*1
|
EM
|
2.0
|
47 (23.6)
|
–
|
35 (30.7)
|
12 (14.6)
|
|
*1/*2
|
EM
|
2.0
|
45 (22.6)
|
3 (100)
|
40 (35.1)
|
2 (2.4)
|
|
*2/*2
|
EM
|
2.0
|
27 (13.6)
|
–
|
21 (18.4)
|
6 (7.3)
|
-
aCYP2D6 poor metabolizers (PM), intermediate metabolizers (IM), extensive metabolizers (EM)
-
bCYP2D6 activity score is the sum of the per-allele scores; a null allele having a score of 0, a deficient allele a score of 0.5 and a normal allele a score of 1 [12]
