|
Antibody
|
Antigens
|
Burkina Faso
|
Ghana
|
Overall
|
|---|
|
Crude HR (95 % CI)
|
HR adjusted for age (95 % CI)a
|
p value for adjusted HR
|
Crude HR (95 % CI)
|
HR adjusted for age (95 % CI)a
|
p value for adjusted HR
|
Crude HR (95 % CI)b
|
HR adjusted for age (95 % CI)b
|
p value for adjusted HR
|
|---|
|
IgG
|
GLURP R2
|
0.75 (0.66, 0.85)
|
0.84 (0.73, 0.97)
|
0.01
|
0.77 (0.44, 1.34)
|
0.73 (0.41, 1.30)
|
0.28
|
0.75 (0.66, 0.85)
|
0.85 (0.74, 0.97)
|
0.02
|
|
MSP1-hybrid
|
0.73 (0.61, 0.87)
|
0.83 (0.70, 0.98)
|
0.03
|
1.40 (0.64, 3.08)
|
1.19 (0.57, 2.50)
|
0.64
|
0.75 (0.63, 0.89)
|
0.85 (0.72, 1.01)
|
0.06
|
|
AS202.11
|
0.93 (0.82, 1.05)
|
0.97 (0.87, 1.09)
|
0.65
|
1.37 (0.89, 2.11)
|
1.15 (0.85, 1.56)
|
0.38
|
0.93 (0.82, 1.06)
|
0.98 (0.88, 1.10)
|
0.76
|
|
IgG1
|
GLURP R2
|
0.86 (0.73, 1.00)
|
0.97 (0.82, 1.14)
|
0.68
|
0.93 (0.47, 1.85)
|
0.91 (0.45, 1.86)
|
0.8
|
0.86 (0.74, 1.00)
|
0.97 (0.83, 1.14)
|
0.69
|
|
MSP1-hybrid
|
0.96 (0.75, 1.23)
|
0.96 (0.77, 1.21)
|
0.76
|
1.22 (0.78, 1.92)
|
1.03 (0.67, 1.58)
|
0.91
|
1.00 (0.80, 1.25)
|
1.01 (0.82, 1.24)
|
0.94
|
|
IgG2
|
GLURP R2
|
0.74 (0.65, 0.83)
|
0.85 (0.75, 0.96)
|
0.01
|
1.45 (0.71, 2.97)
|
1.24 (0.64, 2.43)
|
0.52
|
0.74 (0.66,0.84)
|
0.86 (0.76, 0.98)
|
0.02
|
|
MSP1-hybrid
|
0.73 (0.59, 0.91)
|
0.87 (0.70, 1.08)
|
0.2
|
1.19 (0.47, 3.01)
|
1.17 (0.51, 2.67)
|
0.72
|
0.74 (0.60, 0.92)
|
0.89 (0.72, 1.10)
|
0.27
|
|
IgG3
|
GLURP R2
|
0.73 (0.66, 0.81)
|
0.81 (0.73, 0.90)
|
<0.0001
|
0.48 (0.25, 0.93)
|
0.54 (0.30, 0.98)
|
0.04
|
0.73 (0.66, 0.81)
|
0.81 (0.73, 0.90)
|
<0.0001
|
|
MSP1-hybrid
|
0.85 (0.78, 0.93)
|
0.91 (0.84, 0.99)
|
0.04
|
0.82 (0.38, 1.77)
|
0.83 (0.33, 2.08)
|
0.69
|
0.86 (0.78, 0.94)
|
0.92 (0.84, 1.00)
|
0.05
|
|
IgG4
|
GLURP R2
|
0.79 (0.68, 0.92)
|
0.85 (0.73, 0.98)
|
0.02
|
1.18 (0.31, 4.57)
|
1.30 (0.38, 4.43)
|
0.68
|
0.79 (0.68, 0.92)
|
0.85 (0.73, 0.98)
|
0.02
|
|
MSP1-hybrid
|
0.95 (0.83, 1.09)
|
0.97 (0.85, 1.11)
|
0.65
|
1.14 (0.32, 4.03)
|
0.82 (0.29, 2.31)
|
0.7
|
0.95 (0.83, 1.09)
|
0.98 (0.86, 1.11)
|
0.73
|
|
IgM
|
GLURP R2
|
0.66 (0.55, 0.79)
|
0.77 (0.63, 0.95)
|
0.01
|
0.70 (0.14, 3.57)
|
1.14 (0.24, 5.40)
|
0.87
|
0.66 (0.55, 0.79)
|
0.78 (0.64, 0.95)
|
0.02
|
|
MSP1-hybrid
|
0.72 (0.63, 0.84)
|
0.81 (0.70, 0.94)
|
0.01
|
1.42 (0.25, 8.07)
|
1.68 (0.36, 7.93)
|
0.51
|
0.73 (0.63, 0.84)
|
0.82 (0.70, 0.95)
|
0.01
|
|
AS202.11
|
0.86 (0.74, 0.99)
|
0.92 (0.80, 1.05)
|
0.23
|
0.58 (0.23, 1.45)
|
0.70 (0.26, 1.90)
|
0.49
|
0.85 (0.74, 0.98)
|
0.92 (0.80, 1.06)
|
0.23
|
- Crude hazard ratios (HR) as well as age-adjusted HR and p values are shown, indicating the ratio of malaria hazard rates associated with a tenfold increase in baseline antibody level
-
a95 % CI were estimated using Cox regression model with robust standard error to adjust for clustering in children
-
bStratified estimates (i.e., equal coefficients across sites but with baseline hazard unique to each site)
