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Table 4 Adjusted hazard ratios for immunological variables independently associated with malaria risk in the final model

From: Antibody levels against GLURP R2, MSP1 block 2 hybrid and AS202.11 and the risk of malaria in children living in hyperendemic (Burkina Faso) and hypo-endemic (Ghana) areas

Sites Immunological/age variables Adjusted HR (95 % CI) Wald p value
Burkina Faso GLURP R2 IgG3 (values transformed to log base 10) 0.82 (0.74, 0.91) p < 0.0001
MSP1-hybrid IgM (values transformed to log base 10) 0.85 (0.73, 0.98) p = 0.02
Age group (months)
 6–23 1 p < 0.0001
 24–35 1.12 (0.91, 1.38)
 36–47 0.82 (0.62, 1.07)
 48–60 0.44 (0.31, 0.63)
Ghana GLURP R2 IgG3 (values transformed to log base 10) 0.48 (0.25, 0.91) p = 0.02
AS202.11 IgG (values transformed to log base 10) 1.29 (1.01, 1.65) p = 0.04
Age group (months)
 6–23 1 p < 0.01
 24–35 0.14 (0.04, 0.48)
 36–47 0.14 (0.04, 0.48)
 48–72 0.19 (0.07, 0.55)
  1. Hazard ratios (HR) indicates the ratio of malaria hazard rates associated with a ten-fold increase in baseline antibody level