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Table 1 Numbers of non-synonymous mutations in Plasmodium falciparum K13 gene corresponding to amino acids 210–726 in different sites in Myanmar

From: K13 mutations and pfmdr1 copy number variation in Plasmodium falciparum malaria in Myanmar

 

Ann

Homemalin

Myit Kyi Nar

Kyauk Me

Phruso

Total

Total n

64

91

32

13

6

206

Wild type

61**

59**

6

0

4

126

Non-propeller mutations

 R254L*

  

1

  

1

 R255K

 

2

   

2

 E294G*

 

1

   

1

 I352T

 

2

   

2

 R411K*

 

1

   

1

 Total

0

6

1

0

0

7

 %

0

6.6

3.2

0

0

3.4

 (95 % CI)

(0.0–5.7)

(3.0–13.6)

(0.56–15.8)

(0–22.8)

(0–39.0)

(1.7–6.8)

Propeller mutations

 P441L

  

1

  

1

 P443S

 

3

   

3

 F446I

 

13

18

1

 

32

 G449A

1

   

1

2

 S485N

    

1

1

 Y511H*

  

1

  

1

 A529T*

 

1

   

1

 N554L*

1

    

1

 P574L

1

 

2

12

 

15

 R561H

 

1

   

1

 R575K

 

1

   

1

 A675V

 

2

   

2

 A676D

 

4

3

  

7

 H719N

 

1

   

1

 Total

3

26

25

13

2

69

 %

4.7

28.6

78.1

100

33.3

33.5

 (95 % CI)

(1.6–12.9)

(20.3–38.6)

(61.2–89.0)

(77.2–100)

(9.7–70.0)

(27.4–40.2)

  1. * Newly identified mutations from this study
  2. ** Includes single samples with previously unreported synonymous mutations in Ann (E424E) and Homemalin (D343D)