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Table 1 Published case reports of severe thrombocytopaenia associated with severe Plasmodium vivax malaria

From: Imported Plasmodium vivax malaria with severe thrombocytopaenia: can it be severe malaria or not?

Year of publication/reference Location of malaria acquisition Age/sex Platelet count/μL (nadir) Other complications Diagnostic method/parasite density P. falciparum excluded Treatment/platelets transfusion (N unit) Outcome
1997/[15] Thailand 27/F 22.000 No Microscopy/serology/0.6 % Yes Sulfadoxine-pyrimethamine + primaquine/no Recovery
1998/[24] India 20/M 14.000 Severe anemia (Hb 3 g/dL) Microscopy/NR No Chloroquine + primaquine/no Recovery
1999/[11] India 43/F 5.000 No Microscopy/RDT/NR Yes Chloroquine + primaquine/no Recovery
1999/[11] Colombia 32/M 17.000 Shock; ARDS Microscopy/PCR/5 % Yes Quinidine + primaquine/no Recovery
2002/[12] India 43/M 8.000 No Microscopy/RDT/NR Yes Quinine sulphate/yes (6 units) Recovery
2003/[26] India 29/M 35.000 Jaundice Microscopy/PCR/<1 % Yes Chloroquine + primaquine/no Recovery
2003/[27] Mexico 30/M 6.000 Epistaxis Microscopy/NR No Quinine + doxycycline switched to chloroquine + primaquine/yes (20 units) Recovery
2004/[28] Brazil 20/M 2.000 Petechiae, hemorrhagic bullae Microscopy/PCR/NR Yes Chloroquine/yes (1 unit)/prednisone Recovery ITPa
2005/[29] Brazil 43/F 17.000 ARDS; shock Microscopy/RDT/NR Yes Chloroquine + artemether + primaquine/No Recovery
2005/[30] India 7/M 6.000 Petechial rash, gum bleeding Microscopy/bone marrow/NR No Chloroquine (1 dose) followed by quinine dihydrochloride + primaquine/yes (2 units)/steroids Recovery
2006/[31] Venezuela 50/F 25.000 ARDS Microscopy/PCR/1200/μL Yes Mefloquine + primaquine/no Recovery
2006/[32] Turkey 22 days/F 17.000 Jaundice Microscopy/NR No Chloroquine + primaquine/yes (NR) Recovery
2007/[33] Guyana 59/M 10.000 ARDS; shock; renal failure Microscopy/PCR/5 % Yes Quinine sulphate + doxycycline switched to intravenous quinidine/yes (1 unit) Recovery
2007/[34] Pakistan 59/M 39.000 ARDS; renal failure Microscopy/RDT/PCR/3 % Yes Chloroquine + primaquine/no Recovery
2007/[35] India 8/M 30.000 Renal failure; petechial rash Microscopy/RDT/24.000/μL Yes Quinine dihydrochloride/no Recovery
2007/[36] Republic of Korea 21/M 25.000 Shock Microscopy/RDT/PCR/2352/μL Yes Chloroquine + primaquine/no Recovery
2007/[36] Republic of Korea 33/M 40.000 Shock Microscopy/RDT/12.376/μL Yes Chloroquine + primaquine/no Recovery
2008/[37] Brazil 14/M 6.000 No Microscopy/bone marrow/PCR/NR Yes Chloroquine + primaquine/no Recovery
2009/[38] India 4/F 11.000 Shock; bleeding; increased liver enzymes (AST 1080 U/L) Microscopy/bone marrow/PCR/RDT/ Yes Artesunate + mefloquine + primaquine + immunoglobulin/yes Recovery
2009/[39] Republic of Korea 27/F 21.000 Myocarditis Microscopy/PCR/6990/μL Yes Chloroquine/no Recovery
2009/[40] India 1/M 20.000 Severe anemia; intracranial bleeding; seizures Microscopy/RDT/NR No Cloroquine + quinine dihydrochloride +primaquine/yes Recovery with hydrocephalus
2010/[41] Republic of Korea 52/M 40.000 Retinal hemorrhage; jaundice; spleen infarction Microscopy/9188/μL No Chloroquine + primaquine/no Recovery
2010/[42] Brazil 16/M 12.000 Rhabdomyolysis, renal failure Microscopy/PCR/1520/μL Yes Chloroquine + artesunate + clindamycin/no Recovery
2010/[43] India 8/F 21.000 Petechial rash; severe anemia (Hb 4.7 g/dL); hematemesis Microscopy/bone marrow/RDT/1.5 % Yes Chloroquine + primaquine/no Recovery
2010/[43] India 4/F 35.000 Epistaxis; melena Microscopy/RDT/NR Yes Chloroquine + primaquine/yes (NR) Recovery
2011/[44] India 50/M 19.000 ARDS, hypotension Microscopy/NR No Artesunate + primaquine/no Recovery
2012/[45] India 17/M 34.000 Acute pancreatitis; shock Microscopy/RDT/NR Yes NR/No Died
2013/[46] Malaysia 38/M 41.000 ARDS Microscopy/PCR/16/μL Yes Artesunate + primaquine/no Recovery
2013/[47] India 19/F 45.000 Acute myocarditis Microscopy/RDT/NR Yes Artesunate + doxycycline/no Recovery
2013/[48] India 11/M 27.000 Petechial rash; jaundice; acute renal failure; GI bleeding, shock Microscopy/RDT/NR No Artesunate/yes (NR) Recovery
2013/[49] Republic of Korea 59/M 37.000 ARDS; acute renal failure; jaundice; lactic acidosis Microscopy/RDT/16,380/μL Yes Artesunate + chloroquine + primaquine/no Recovery
2014/[50] Greece 42/F 24.000 ARDS; jaundice Microscopy/PCR//0.007 % Yes Mefloquine + quinine + doxycycline + primaquine/no Recovery
2014/[51] India 8/F 11.000 GCS 7; haemophagocytic syndrome; acute renal failure; hypotension Microscopy/bone marrow/RDT/NR Yes Artesunate + sulphadoxine-pyrimethamine + primaquine/no Recovery
  1. F female, M male, Hb haemoglobin, NR not reported, RDT rapid diagnostic tests, ARDS acute respiratory distress syndrome, PCR polymerase chain reaction, a ITP idiopathic thrombocytopaenic purpura, AST alanine aminotransferase, GCS Glasgow Coma Score, GI gastrointestinal