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Table 2 Comparison of contents of ARS and MFQ in tablets by MIR-PLS and HPLC–MS/MS (n = 5)

From: Simultaneous quantification of artesunate and mefloquine in fixed-dose combination tablets by multivariate calibration with middle infrared spectroscopy and partial least squares regression

 

Mean values ± dp (n = 3)a

P value b

MIR-PLS

HPLC–MS/MS

ARS

23.40 ± 0.50

22.84 ± 0.55

0.258

22.78 ± 0.43

22.24 ± 0.46

0.220

23.73 ± 0.27

22.77 ± 0.55

0.054

23.20 ± 1.52

21.55 ± 0.16

0.135

22.52 ± 0.11

22.63 ± 0.29

0.550

MFQ

49.15 ± 1.72

50.11 ± 0.75

0.428

53.77 ± 1.91

51.17 ± 0.89

0.100

51.67 ± 1.31

51.06 ± 0.22

0.471

54.14 ± 3.59

52.90 ± 0.28

0.584

52.16 ± 2.55

50.26 ± 0.13

0.266

  1. amg/100 mg of tablet
  2. bt test non-paired, at 95 % confidence level
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Malaria Journal

ISSN: 1475-2875

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