Fig. 2

Peptide monoclonal antibodies directed against Plasmodium falciparum Plasmepsin VII and Plasmepsin X. a Schematic representation of Plasmepsin showing the predicted signal peptide (blank), pro-enzyme domains (pro), and catalytic domain (cat). Peptide monoclonal antibodies designed against three regions of PfPM VII and PfPM X are designated prodomain (PD, black), catalytic domain 1 (CD1, red) and catalytic domain 2 (CD2, purple). b Protein sequence of PfPM VII and c. PfPM X showing the predicted signal peptide (blue) and the predicted pro-enzyme domain (italics); the two active aspartic acid residues (red) are found within conserved regions (bold). Monoclonal antibody targets to prodomain (black), CD1 (red), and CD 2 (purple). d Alignment of 3G6 peptide target between all P. falciparum plasmepsins shows moderate conservation between PfPM X and PfPM IX at this site