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Table 1 Effect of mAbs against PfPM VII on Plasmodium falciparum infectivity to Anopheles stephensi mosquitoes

From: Plasmodium falciparum ookinete expression of plasmepsin VII and plasmepsin X

Exp Group Intensity (geometric mean oocysts/mosquito) Oocyst range Prevalence (no. infected/total engorged mosquitoes)
1 200 μg/ml IgG negative 2.28 0–10 31/39 (79.5 %)
200 μg/ml 1B4 0.07* 0–2 3/37 (8.1 %)
400 μg/ml IgG negative 22.18 7–58 24/24 (100 %)
400 ug/ml 2B1 7.7* 0–54 13/17 (76.5 %)
2 200 μg/ml IgG negative 24.23 0–121 34/40 (85.0 %)
200 μg/ml 1B4 3.47* 0–45 20/40 (50.0 %)
400 μg/ml IgG negative 9.15 0–88 29/38 (76.3 %)
400 μg/ml 2B1 3.17* 0–81 20/33 (66.6 %)
3 200 μg/ml IgG negative 12.67 0–55 35/40 (87.5 %)
200 μg/ml 1B4 2.41* 0–29 8/19 (42.1 %)
400 μg/ml IgG negative 14.74 0–68 31/32 (96.9 %)
400 μg/ml 2B1 6.5* 0–65 29/34 (85.3 %)
  1. mAbs and IgG isotype control data from three independent SMFAs. Transmission-blocking activities measured as effects on intensity and prevalence.
  2. * Statistical significance determined by Mann–Whitney U test, control versus mAb, p value ≤0.01