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Table 1 Effect of mAbs against PfPM VII on Plasmodium falciparum infectivity to Anopheles stephensi mosquitoes

From: Plasmodium falciparum ookinete expression of plasmepsin VII and plasmepsin X

Exp

Group

Intensity (geometric mean oocysts/mosquito)

Oocyst range

Prevalence (no. infected/total engorged mosquitoes)

1

200 μg/ml IgG negative

2.28

0–10

31/39 (79.5 %)

200 μg/ml 1B4

0.07*

0–2

3/37 (8.1 %)

400 μg/ml IgG negative

22.18

7–58

24/24 (100 %)

400 ug/ml 2B1

7.7*

0–54

13/17 (76.5 %)

2

200 μg/ml IgG negative

24.23

0–121

34/40 (85.0 %)

200 μg/ml 1B4

3.47*

0–45

20/40 (50.0 %)

400 μg/ml IgG negative

9.15

0–88

29/38 (76.3 %)

400 μg/ml 2B1

3.17*

0–81

20/33 (66.6 %)

3

200 μg/ml IgG negative

12.67

0–55

35/40 (87.5 %)

200 μg/ml 1B4

2.41*

0–29

8/19 (42.1 %)

400 μg/ml IgG negative

14.74

0–68

31/32 (96.9 %)

400 μg/ml 2B1

6.5*

0–65

29/34 (85.3 %)

  1. mAbs and IgG isotype control data from three independent SMFAs. Transmission-blocking activities measured as effects on intensity and prevalence.
  2. * Statistical significance determined by Mann–Whitney U test, control versus mAb, p value ≤0.01