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Table 2 Effect of mAbs against PfPM X on Plasmodium falciparum infectivity to Anopheles gambiae mosquitoes

From: Plasmodium falciparum ookinete expression of plasmepsin VII and plasmepsin X

Group

Intensity (geometric mean oocysts/mosquito)

Oocyst range

Prevalence (no. infected/total engorged mosquitoes)

200 μg/ml IgG negative

2.6

0–55

62/80 (77.5 %)

100 μg/ml 3G6

1.7

0–108

48/80 (60.0 %)

200 μg/ml 3G6

1.5*

0–148

34/76 (44.7 %)

200 μg/ml 6A9

2.4

0–59

33/51 (64.7 %)

  1. mAbs and IgG isotype control data from triplicate SMFAs under the same conditions, data combined. Transmission-blocking activities measured as effects on intensity and prevalence
  2. * Statistical significance determined by Mann–Whitney U test, control versus mAb, p value ≤0.01
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Malaria Journal

ISSN: 1475-2875

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