Skip to main content

Table 2 Effect of mAbs against PfPM X on Plasmodium falciparum infectivity to Anopheles gambiae mosquitoes

From: Plasmodium falciparum ookinete expression of plasmepsin VII and plasmepsin X

Group Intensity (geometric mean oocysts/mosquito) Oocyst range Prevalence (no. infected/total engorged mosquitoes)
200 μg/ml IgG negative 2.6 0–55 62/80 (77.5 %)
100 μg/ml 3G6 1.7 0–108 48/80 (60.0 %)
200 μg/ml 3G6 1.5* 0–148 34/76 (44.7 %)
200 μg/ml 6A9 2.4 0–59 33/51 (64.7 %)
  1. mAbs and IgG isotype control data from triplicate SMFAs under the same conditions, data combined. Transmission-blocking activities measured as effects on intensity and prevalence
  2. * Statistical significance determined by Mann–Whitney U test, control versus mAb, p value ≤0.01