Skip to main content

Table 4 Comparison of slope values for concentration-effect curves of anti-malarial drugs against Plasmodium falciparum and Plasmodium vivax

From: Analysis of ex vivo drug response data of Plasmodium clinical isolates: the pros and cons of different computer programs and online platforms

 

P. falciparum

 

P. vivax

Method

Geometric mean slope (95 % CI)

Median difference slopea (range)

Method

Geometric mean slope (95 % CI)

Median difference slopea (range)

Chloroquine (n = 31)

NONMEM

3.09 (2.72–3.46)

 

Chloroquine (n = 29)

NONMEM

3.86 (2.99–4.72)

 

GP

3.15 (2.66–3.73)

0.03 (−0.20 to 4.85)

GP

3.48 (2.75–4.39)

0.06 (−0.46 to 2.82)

ICE

3.33 (2.84–3.91)

0.17 (0.03 to 4.85)

ICE

3.67 (2.93–4.60)

0.20 (−0.46 to 2.82)

IVART

3.40 (2.91–3.97)

0.23 (−1.67 to 4.69)

IVART

3.55 (2.85–4.42)

0.21 (−2.20 to 4.90)

WNL

3.08 (2.64–3.59)

0.01 (−0.18 to 2.88)

WNL

3.43 (2.71–4.35)

0.03 (−0.46 to 2.82)

Piperaquine (n = 31)

NONMEM

3.17 (2.58–3.76)

 

Piperaquine (n = 28)

NONMEM

3.80 (3.17–4.43)

 

GP

3.13 (2.54–3.85)

0.08 (−0.50 to 3.63)

GP

3.88 (3.03–4.96)

0.02 (0.29 to 4.32)

ICE

3.21 (2.59–3.96)

0.21 (−0.07 to 3.63)

ICE

4.13 (3.26–5.25)

0.26 (0.03 to 4.32)

IVART

3.07 (2.47–3.82)

0.20 (−2.59 to 4.60)

IVART

4.06 (3.24–5.09)

0.26 (−0.92 to 4.32)

WNL

2.83 (2.37–3.37)

0.01 (−0.52 to 3.61)

WNL

3.82 (3.01–4.86)

−0.01 (−0.26 to 4.16)

Mefloquine (n = 31)

NONMEM

2.48 (2.18–2.78)

 

Mefloquine (n = 29)

NONMEM

2.96 (2.53–3.38)

 

GP

2.46 (2.10–2.89)

0.03 (−0.15 to 5.04)

GP

3.11 (2.48–3.91)

0.01 (−0.23 to 5.07)

ICE

2.60 (2.24–3.02)

0.19 (0.01 to 5.04)

ICE

3.25 (2.64–4.00)

0.18 (0.04 to 5.19)

IVART

2.38 (2.05–2.75)

0.08 (−0.86 to 0.92)

IVART

3.04 (2.53–3.65)

0.19 (−1.63 to 5.19)

WNL

2.42 (2.08–2.83)

0.02 (−0.15 to 4.21)

WNL

3.02 (2.41–3.78)

−0.01 (−0.69 to 5.05)

Amodiaquine (n = 30)

NONMEM

4.43 (3.37–5.50)

 

Amodiaquine (n = 28)

NONMEM

3.95 (3.26–4.65)

 

GP

3.68 (2.89–4.70)

0.06 (−0.37 to 4.67)

GP

3.89 (3.03–4.98)

0.06 (−0.54 to 4.50)

ICE

4.01 (3.22–5.00)

0.24 (0.03 to 4.67)

ICE

4.12 (3.28–5.18)

0.19 (−0.24 to 4.50)

IVART

4.01 (3.22–5.00)

0.24 (0.03 to 4.67)

IVART

4.17 (3.33–5.24)

0.19 (−0.24 to 4.50)

WNL

3.64 (2.86–4.63)

0.05 (−0.43 to 3.67)

WNL

3.87 (3.03–4.95)

0.02 (0.28 to 4.47)

Artesunate (n = 31)

NONMEM

2.74 (2.38–3.10)

 

Artesunate (n = 28)

NONMEM

2.74 (2.38–3.10)

 

GP

2.63 (2.19–3.15)

−0.05 (−0.35 to 4.55)

GP

3.67 (2.75–4.89)

0.18 (−0.54 to 4.79)

ICE

2.94 (2.49–3.46)

0.20 (0.35 to 4.55)

ICE

3.92 (3.01–5.10)

0.24 (0.01 to 4.79)

IVART

3.03 (2.52–3.65)

0.32 (−0.68 to 7.12)

IVART

3.84 (2.94–5.01)

0.18 (−0.38 to 4.38)

WNL

2.63 (2.19–3.15)

−0.01 (−0.37 to 4.51)

WNL

3.64 (2.76–4.79)

0.14 (−0.31 to 4.49)

  1. aMedian difference (range) for each method compared with NONMEM (values in italics) used as the reference method for comparison