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Table 4 Comparison of slope values for concentration-effect curves of anti-malarial drugs against Plasmodium falciparum and Plasmodium vivax

From: Analysis of ex vivo drug response data of Plasmodium clinical isolates: the pros and cons of different computer programs and online platforms

  P. falciparum   P. vivax
Method Geometric mean slope (95 % CI) Median difference slopea (range) Method Geometric mean slope (95 % CI) Median difference slopea (range)
Chloroquine (n = 31) NONMEM 3.09 (2.72–3.46)   Chloroquine (n = 29) NONMEM 3.86 (2.99–4.72)  
GP 3.15 (2.66–3.73) 0.03 (−0.20 to 4.85) GP 3.48 (2.75–4.39) 0.06 (−0.46 to 2.82)
ICE 3.33 (2.84–3.91) 0.17 (0.03 to 4.85) ICE 3.67 (2.93–4.60) 0.20 (−0.46 to 2.82)
IVART 3.40 (2.91–3.97) 0.23 (−1.67 to 4.69) IVART 3.55 (2.85–4.42) 0.21 (−2.20 to 4.90)
WNL 3.08 (2.64–3.59) 0.01 (−0.18 to 2.88) WNL 3.43 (2.71–4.35) 0.03 (−0.46 to 2.82)
Piperaquine (n = 31) NONMEM 3.17 (2.58–3.76)   Piperaquine (n = 28) NONMEM 3.80 (3.17–4.43)  
GP 3.13 (2.54–3.85) 0.08 (−0.50 to 3.63) GP 3.88 (3.03–4.96) 0.02 (0.29 to 4.32)
ICE 3.21 (2.59–3.96) 0.21 (−0.07 to 3.63) ICE 4.13 (3.26–5.25) 0.26 (0.03 to 4.32)
IVART 3.07 (2.47–3.82) 0.20 (−2.59 to 4.60) IVART 4.06 (3.24–5.09) 0.26 (−0.92 to 4.32)
WNL 2.83 (2.37–3.37) 0.01 (−0.52 to 3.61) WNL 3.82 (3.01–4.86) −0.01 (−0.26 to 4.16)
Mefloquine (n = 31) NONMEM 2.48 (2.18–2.78)   Mefloquine (n = 29) NONMEM 2.96 (2.53–3.38)  
GP 2.46 (2.10–2.89) 0.03 (−0.15 to 5.04) GP 3.11 (2.48–3.91) 0.01 (−0.23 to 5.07)
ICE 2.60 (2.24–3.02) 0.19 (0.01 to 5.04) ICE 3.25 (2.64–4.00) 0.18 (0.04 to 5.19)
IVART 2.38 (2.05–2.75) 0.08 (−0.86 to 0.92) IVART 3.04 (2.53–3.65) 0.19 (−1.63 to 5.19)
WNL 2.42 (2.08–2.83) 0.02 (−0.15 to 4.21) WNL 3.02 (2.41–3.78) −0.01 (−0.69 to 5.05)
Amodiaquine (n = 30) NONMEM 4.43 (3.37–5.50)   Amodiaquine (n = 28) NONMEM 3.95 (3.26–4.65)  
GP 3.68 (2.89–4.70) 0.06 (−0.37 to 4.67) GP 3.89 (3.03–4.98) 0.06 (−0.54 to 4.50)
ICE 4.01 (3.22–5.00) 0.24 (0.03 to 4.67) ICE 4.12 (3.28–5.18) 0.19 (−0.24 to 4.50)
IVART 4.01 (3.22–5.00) 0.24 (0.03 to 4.67) IVART 4.17 (3.33–5.24) 0.19 (−0.24 to 4.50)
WNL 3.64 (2.86–4.63) 0.05 (−0.43 to 3.67) WNL 3.87 (3.03–4.95) 0.02 (0.28 to 4.47)
Artesunate (n = 31) NONMEM 2.74 (2.38–3.10)   Artesunate (n = 28) NONMEM 2.74 (2.38–3.10)  
GP 2.63 (2.19–3.15) −0.05 (−0.35 to 4.55) GP 3.67 (2.75–4.89) 0.18 (−0.54 to 4.79)
ICE 2.94 (2.49–3.46) 0.20 (0.35 to 4.55) ICE 3.92 (3.01–5.10) 0.24 (0.01 to 4.79)
IVART 3.03 (2.52–3.65) 0.32 (−0.68 to 7.12) IVART 3.84 (2.94–5.01) 0.18 (−0.38 to 4.38)
WNL 2.63 (2.19–3.15) −0.01 (−0.37 to 4.51) WNL 3.64 (2.76–4.79) 0.14 (−0.31 to 4.49)
  1. aMedian difference (range) for each method compared with NONMEM (values in italics) used as the reference method for comparison