Table 3 Significant genes differentiating between severe and uncomplicated malaria at the acute illness (function designated by Ingenuity Pathway Analysis)
Gene | Probe | Description | Acute illness log (fold change) | p value |
|---|---|---|---|---|
MB21D1 | 1559051_s_at | Mab-21 domain containing 1 | −1.482461 | 3.64E−04 |
SAMSN1 | 1555638_a_at | SAM domain, SH3 domain and nuclear localization signals 1 | −1.265117 | 4.52E−04 |
PLBD1 | 218454_at | Phospholipase B domain containing 1 | −1.016165 | 6.47E−04 |
MKRN1 | 209845_at | Makorin ring finger protein 1 | 1.078957 | 9.25E−04 |
PSMF1 | 201053_s_at | Proteasome (prosome, macropain) inhibitor subunit 1 (PI31) | 1.088499 | 1.40E−03 |
HEMGN | 223670_s_at | Haemogen | 1.782966 | 1.41E−03 |
KREMEN1 | 227250_at | Kringle containing transmembrane protein 1 | −1.004677 | 1.47E−03 |
FPR2 | 210772_at | Formyl peptide receptor 2 | −1.121253 | 1.56E−03 |
BCL6 | 215990_s_at | B cell CLL/lymphoma 6 | −1.244554 | 1.71E−03 |
HSPA6 | 117_at | Heat shock 70 kDa protein 6 (HSP70B’) | −1.358852 | 2.02E−03 |
CCR2 | 207794_at | Chemokine (C–C motif) receptor 2 | −1.041326 | 2.11E−03 |
FPR2 | 210773_s_at | Formyl peptide receptor 2 | −1.227297 | 2.23E−03 |
WNK1 | 1555068_at | WNK lysine deficient protein kinase 1 | 1.507248 | 2.25E−03 |
HLA-DPA1 | 211990_at | Major histocompatibility complex, class II, DP alpha 1 | −1.370427 | 2.40E−03 |
SOS1 | 212777_at | Son of sevenless homologue 1 (Drosophila) | −1.564278 | 2.41E−03 |
SAMSN1 | 220330_s_at | SAM domain, SH3 domain and nuclear localization signals 1 | −1.184775 | 2.47E−03 |
GNLY | 205495_s_at | Granulysin | −1.246373 | 2.66E−03 |
TMEM165 | 226825_s_at | Transmembrane protein 165 | −1.055969 | 2.72E−03 |
EIF5A | 201123_s_at | Eukaryotic translation initiation factor 5A | 2.023113 | 2.80E−03 |
CCR2 | 206978_at | Chemokine (C–C motif) receptor 2 | −1.346736 | 2.94E−03 |
C14orf45 | 220173_at | Chromosome 14 open reading frame 45 | 1.49005 | 3.20E−03 |
ITGAM | 205786_s_at | integrin, alpha M (complement component 3 receptor 3 sub-unit) | −1.038506 | 3.30E−03 |
BPGM | 203502_at | 2,3-bisphosphoglycerate mutase | 1.360559 | 3.34E−03 |
FECH | 203116_s_at | Ferrochelatase | 1.547674 | 3.42E−03 |
IRAK3 | 213817_at | Interleukin-1 receptor-associated kinase 3 | −1.445589 | 3.52E−03 |
DUSP1 | 201041_s_at | Dual specificity phosphatase 1 | −1.168216 | 3.64E−03 |
FOS | 209189_at | FBJ murine osteosarcoma viral oncogene homolog | −1.062789 | 3.69E−03 |
TLR8 | 220832_at | Toll-like receptor 8 | −1.131984 | 3.80E−03 |
FOSL2 | 228188_at | FOS-like antigen 2 | −1.020796 | 3.89E−03 |
SRRD | 213608_s_at | SRR1 domain containing | 1.110322 | 3.90E−03 |
NLRC4 | 1552553_a_at | NLR family, CARD domain containing 4 | −1.001566 | 3.91E−03 |
HSPA6 | 213418_at | Heat shock 70 kDa protein 6 (HSP70B’) | −1.327448 | 3.98E−03 |
PSMF1 | 201052_s_at | Proteasome (prosome, macropain) inhibitor subunit 1 (PI31) | 1.021332 | 4.11E−03 |
MS4A6A | 219666_at | Membrane-spanning 4-domains, subfamily A, member 6A | −1.031532 | 4.29E−03 |
DUSP3 | 201537_s_at | Dual specificity phosphatase 3 | −1.024139 | 4.36E−03 |
EGLN1 | 224314_s_at | Egl nine homologue 1 (Caenorhabditis elegans) | −1.036334 | 4.37E−03 |
STEAP4 | 1556185_a_at | STEAP family member 4 | −1.385834 | 4.86E−03 |