B cell sub-types following acute malaria and associations with clinical immunity

Malaria Journal

Table 2 Associations between measures of clinical immunity and proportions of B cell sub-sets

B cell sub-set	Day 0 parasite density <median^a Mean difference in % proportion (p value)		Asymptomatic parasitaemia prior 180 days^b Mean difference in % proportion (p value)
B cell sub-set	Unadjusted	Adjusted^c	Unadjusted	Adjusted^c
Atypical MBCs	4.5 (0.001)	5.1 (<0.001)	1.9 (0.05)	3.8 (0.04)
Transitional	−2.6 (0.08)	−3.6 (0.02)	−0.6 (0.5)	−1.1 (0.3)
Classical MBCs	−0.2 (0.8)	0.4 (0.7)	−0.6 (0.3)	−0.2 (0.7)

Associations were measured using all sampling time points from each participant compared to either day 0 parasite densities or prior episodes of asymptomatic parasitaemia in previous 180 days. Day 0 parasite density ≤ 23,080 parasites/μl n = 20 and > 23,080 parasites/μl n = 18. Of the 38 participants in this study, ten had one or more episodes of asymptomatic parasitaemia in the previous 180 days
Results in italics have a significant analysis adjusted p value
^aMedian parasite density = 23,080 parasites/μl
^bLinear relationship between 0, one and more than one episode
^cAnalysis adjusted for P. falciparum exposure, as estimated by the incidence of malaria in that child between 12 and 24 months of age

ISSN: 1475-2875