Fig. 8

Epitope specificities of anti-PfCyRPA mAbs. a Anti-PfCyRPA mAbs were tested in an Ab–Ab competition ELISA. x Ab competition (signal reduction higher than 30 %; measured values: min. 34 %, max. 91 % reduction), − no Ab competition (measured values: min. −10 %, max. 21 % reduction. b Reactivity of anti-PfCyRPA mAbs with recombinant PfCyRPA fragments were investigated by western blotting analyses performed on lysates of HEK cells expressing recombinant PfCyRPA fragments. x staining, − no staining (an example of the reactivity pattern is reported in Fig. 7b). c Anti-PfCyRPA mAbs were assigned to different epitope groups according to the results from the Ab–Ab competition ELISA and the epitope mapping experiment. d P. falciparum in vitro growth inhibition activity of mAbs