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Table 5 Factors associated with behaviour difficulties and mental health disorders following severe malaria

From: Cerebral malaria is associated with long-term mental health disorders: a cross sectional survey of a long-term cohort

Demographic and clinical features Cerebral malaria exposed children, N = 173 Severe malaria anaemia exposed children, N = 99
  With mental health disorder, n = 18 No mental health disorder, n = 155 p a value With mental health disorder, n = 4 No mental health disorder, n = 95 p a value
Gender, male (%) 12 (66.7) 91 (58.7) 0.515 2 (50.0) 60 (63.2) 0.594
Age on exposure, mean (SD) yr 4.2 (2.1) 4.0 (2.0) 0.693 3.2 (1.9) 3.4 (1.4) 0.812
Duration of fever prior to hospitalization, median (IQR) days 3 (2.5) 3 (2.4) 0.149 3. (3.4) 4 (3.5) 0.695
Profound coma (BCS ≤ 1 or GCS ≤ 6) on admission 7 (38.9) 39 (25.2) 0.212
Seizure recurrences during hospitalization, (%) 13 (72.5) 79 (51.0) 0.087
Admission Hb, mean (SD) in g/dl 7.8 (2.1) 7.1 (2.1) 0.150 4.6 (1.2) 4.6 (2.0) 0.841
Admission lactate, mean (SD) 4.1 (4.4) 4.6 (3.4) 0.588 6.0 (3.0) 5.2 (3.6) 0.694
Hypoglycaemia (blood glucose <2.2 mmol/L) on admission 3 (16.7) 8 (5.2) 0.058 0 (0) 4 (4.4) 0.543
Presence of malaria retinopathy,  % 10 (55.8) 103 (66.5) 0.358
Total duration of coma, median (IQR) hoursb 72.0 (36.0, 115) 48.0 (28.5, 78.7) 0.039
Neurologic sequelae on discharge,  % 9 (50.0) 32 (20.7) 0.006
  1. aStudent’s t test for age, Wilcoxon rank-sum for other continuous variables, χ2 or Fisher’s exact test as appropriate for categorical variables
  2. bTime from onset of coma to regaining full consciousness in hours