Demographic and clinical features | Cerebral malaria exposed children, N = 173 | Severe malaria anaemia exposed children, N = 99 | ||||
---|---|---|---|---|---|---|
With mental health disorder, n = 18 | No mental health disorder, n = 155 | p a value | With mental health disorder, n = 4 | No mental health disorder, n = 95 | p a value | |
Gender, male (%) | 12 (66.7) | 91 (58.7) | 0.515 | 2 (50.0) | 60 (63.2) | 0.594 |
Age on exposure, mean (SD) yr | 4.2 (2.1) | 4.0 (2.0) | 0.693 | 3.2 (1.9) | 3.4 (1.4) | 0.812 |
Duration of fever prior to hospitalization, median (IQR) days | 3 (2.5) | 3 (2.4) | 0.149 | 3. (3.4) | 4 (3.5) | 0.695 |
Profound coma (BCS ≤ 1 or GCS ≤ 6) on admission | 7 (38.9) | 39 (25.2) | 0.212 | – | – | – |
Seizure recurrences during hospitalization, (%) | 13 (72.5) | 79 (51.0) | 0.087 | – | – | – |
Admission Hb, mean (SD) in g/dl | 7.8 (2.1) | 7.1 (2.1) | 0.150 | 4.6 (1.2) | 4.6 (2.0) | 0.841 |
Admission lactate, mean (SD) | 4.1 (4.4) | 4.6 (3.4) | 0.588 | 6.0 (3.0) | 5.2 (3.6) | 0.694 |
Hypoglycaemia (blood glucose <2.2 mmol/L) on admission | 3 (16.7) | 8 (5.2) | 0.058 | 0 (0) | 4 (4.4) | 0.543 |
Presence of malaria retinopathy, % | 10 (55.8) | 103 (66.5) | 0.358 | – | – | – |
Total duration of coma, median (IQR) hoursb | 72.0 (36.0, 115) | 48.0 (28.5, 78.7) | 0.039 | – | – | – |
Neurologic sequelae on discharge, % | 9 (50.0) | 32 (20.7) | 0.006 | – | – | – |