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Fig. 1 | Malaria Journal

Fig. 1

From: Recent advances in the biology and drug targeting of malaria parasite aminoacyl-tRNA synthetases

Fig. 1

Generalized two step aminoacylation reaction. In the first step, specific amino acid (AA) is combined with ATP molecule to form a tightly bound aminoacyl-adenylate complex (AA-AMP) by release of pyrophosphate (PPi) and help of a divalent cation. In second step, the activated amino acid is transferred to the 3′ end of cognate tRNA molecule to form charged tRNA (AA-tRNA) with release of AMP. These charged tRNA molecules are then used by ribosomes for protein translation

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