Fig. 4

Structures of two drug targets LysRS and ProRS from malaria parasite are shown in drug bound forms. Upper panel left shows PfLysRS bound to cladosporin (orange) and l-lysine (blue). Upper panel right shows cladosporin bound to PfLysRS active site. Cladosporin binding is achieved by stacking and hydrogen bonding (shown in dotted lines) interactions with the inhibitor. Red dot denotes water molecule. Lower panel left shows halofuginone (light blue) and ATP mimic (yellow) bound surface view of ProRS crystal structure. Lower panel right shows halofuginone binding in the active site and major interacting residues. Halofuginone biding is stabilized by the ATP binding which makes hydrogen bonds with the inhibitor. Hydrogen bonds are denoted as dotted lines