From: Differential kinetic profiles and metabolism of primaquine enantiomers by human hepatocytes
 | (±)-PQ | (+)-PQ | (−)-PQ |
---|---|---|---|
Time interval (min) for calculation of elimination rate constant | 0–60 | 0–60 | 0–60 |
λ (h−1)a | 0.34 | 0.19 | 0.64 |
t½ (h)b | 2.03 | 3.62 | 1.09 |
t½ (min) | 121.8 | 217 | 65 |
CLint in vitro [(mL/h)/million cellsc] | 0.273 | 0.153 | 0.509 |
CLint in vitro [(µL/min)/million cells] | 4.55 | 2.55 | 8.49 |
CLint in vivo [(L/h)/kg body mass]d | 0.69 | 0.39 | 1.30 |
CLint in vivo [(mL/min)/kg body mass] | 11.58 | 6.49 | 21.60 |
CLh,b [(L/h)/kg body mass]e | 0.45 | 0.30 | 0.63 |
CLh,b [(mL/min)/kg body mass] | 7 | 5 | 11 |
CLh,b (% hepatic blood flow)f | 36 | 24 | 51 |