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Fig. 4 | Malaria Journal

Fig. 4

From: In vivo efficacy of artemether-lumefantrine and artesunate-amodiaquine for uncomplicated Plasmodium falciparum malaria in Malawi, 2014

Fig. 4

Aspartate transaminase (AST)* and alanine transaminase (ALT)* levels on day 0 and day 7 among participants randomized to ASAQ, Malawi, 2014. *Normal range: ALT: 0–50 U/L; AST: 0–60 U/L. ALT and AST data at both time points available for 28 and 30 participants, respectively. ALT: Day 0 median 42.3 U/L (range: 6.4 U/L, 80.3 U/L; Interquartile range (IQR): 15 U/L, 53.2 U/L); Day 7 median 16.6 U/L (range: 6.5 U/L, 65.7 U/L; IQR: 12.1 U/L, 40.6 U/L); median difference between day 0 and day 7: −9.4 U/L, p = 0.009. AST: Day 0 median 50.6 U/L (range: 21.2 U/L, 122.6 U/L; IQR: 38.8 U/L, 61.9 U/L); Day 7, median 37.1 U/L (range: 17.6 U/L, 106 U/L; IQR: 27.9 U/L, 48.7 U/L); median difference between day 0 and day 7: −13.4 U/L; p = 0.002. No participants had AST or ALT values more than 2.5 times the upper limit of normal at any time

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