Fig. 2

Goodness-of-fit diagnostics of the final population pharmacokinetic model for paracetamol in patients with falciparum malaria. a observed concentrations plotted against population predictions, b observed concentrations plotted against individually predicted concentrations, c conditionally weighted residual plotted against time after dose, and d conditionally weighted residual plotted against population predictions. Observations are represented by black circles, solid black lines represents the line of identity or zero line, and the local polynomial regression fitting for all observations is represented by the dashed black line. The observed paracetamol concentrations, population predictions and individual predictions were transformed into their logarithms (base 10)