Fig. 4

Simulations from the final population pharmacokinetic model for paracetamol. The lower and upper dashed lines represent the therapeutic plasma concentration range of paracetamol for fever control (10–20 mg/l) [23, 24]. Upper panel population mean plasma concentration–time profiles after intramuscular (IM) administration of a study dosing regimen; 600 mg every 4 h, b normal dosing regimen; 1000 mg every 6 h and c modified dosing regimen; 1500 mg loading dose followed by 1000 mg every 6 h. Lower panel population mean plasma concentration–time profiles after oral syrup (PO) administration of d study dosing regimen; 600 mg every 4 h, e normal dosing regimen; 1000 mg every 6 h and f modified dosing regimen; 1500 loading followed by 1000 mg every 6 h