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Table 1 Baseline characteristics stratified by treatment group

From: Pharmacokinetic properties of intramuscular versus oral syrup paracetamol in Plasmodium falciparum malaria

Variable Total Group 1 Group 2
(n = 21) (n = 10) (n = 11)
Age (years) 25 (22–37; 15,54) 23 (20–30; 15,37) 33 (22–52; 20–54)
Males (%)a 19 (90) 9 (90) 10 (91)
Weight (kg) 58 (55–63; 47,70) 60 (58–65; 55,70) 55 (50–60; 47,70)
Temperature (°C) 39.6 (39.0–40.5; 38.1,41.2) 40.1 (38.2–40.5; 38.1,41.2) 39.4 (39.0–40.5, 38.6,40.8)
Heart rate (beats/min) 100 (92–115; 80,122) 109 (95–120; 92,122) 94 (90–104; 80,120)
Parasitaemia (parasites/μl)b 47,573 (19,769–114,477) 46,793 (13,117–166,929) 48,293 (11,436–203,926)
Haematocrit (%) 44 (38–46; 22,54) 44 (36–45; 34,51) 45 (41–48; 22,54)
Creatinine (μmol/l) 101 (87–112; 70,136) 99 (83–113; 70,131) 105 (92–111; 81,136)
BUN (mg/dl) 16 (15–22; 12,34) 15 (14–21; 13,34) 16 (15–22; 12,29)
AST (IU/l) 40 (27–49; 14,132) 32 (26–42; 14,67) 45 (30–52; 25,132)
ALT (IU/l) 16 (10–28; 9,40) 11 (10–15; 9,28) 26 (16–36; 9,40)
ALP (IU/l) 88 (69–105; 54,311) 72 (63–96; 54,218) 98 (87–116; 70,311)
Total bilirubin (mg/dl) 1.6 (1.2–2.2; 0.6,6.9) 1.9 (1.5–2.4, 1.0,2.7) 1.3 (0.9–1.6; 0.6,6.9)
Indirect bilirubin (mg/dl) 0.4 (0.3–0.5; 0.2,2.4) 0.5 (0.4–0.6; 0.2,0.7) 0.4 (0.3–0.4, 0.2,2.4)
  1. All values are compared using the Mann U Whitney test and reported as median (IQR; range), unless otherwise specified
  2. BUN blood urea nitrogen, AST aspartate transaminase, ALT alanine transaminase, ALP alkaline phosphatase
  3. aReported as number (%) and compared using the Fisher’s exact test
  4. bReported as geometric mean (95 % CI) and compared using the Student’s t-test. Group 1 Oral syrup paracetamol on day 0 then intramuscular paracetamol on day 1; Group 2 Intramuscular paracetamol on day 0 then oral syrup paracetamol on day 1