Parameter | Population estimatea
(%RSE)b
| 95Â % CIb
| IIV (%CV)a
(%RSE)b
| 95Â % CIb
|
|---|
FIM
| 1 fixed | – | – | – |
FPO
| 0.844 (8.4) | 0.682–0.951 | 287 (49.1) | 76.5–1038 |
DURIM (h) | 0.689 (6.2) | 0.621–0.784 | – | – |
ka,PO (h−1) | 4.15 (44.5) | 1.95–9.73 | 232 (49.7) | 39.9–574 |
CL (l/h) | 10.7 (16.9) | 7.35–14.7 | 81.8 (69.7) | 24.4–164 |
VC (l) | 45.5 (8.5) | 36.7–51.5 | – | – |
Q (l/h) | 10.3 (36.8) | 4.80–20.1 | 77.4 (44.0) | 21.1–105 |
VP (l) | 11.3 (42.7) | 5.01–29.0 | 428 (46.5) | 112–2351 |
σ | 0.376 (7.8) | 0.316–0.436 | – | – |
-
F
IM
bioavailability after intramuscular administration, F
PO
relative bioavailability after oral syrup administration, DUR
IM
duration of zero-order absorption after intramuscular administration, k
a,PO
absorption rate constant after oral syrup administration, CL apparent elimination clearance, V
C
apparent volume of distribution of the central compartment, Q inter-compartment clearance, V
P
apparent volume of distribution of the peripheral compartment, σ variance of the residual variability
-
aPopulation mean values and inter-individual variability (IIV) estimated by NONMEM. The coefficient of variation (% CV) for IIV was calculated as \(100 \times \sqrt {\exp ({\text{estimate}}){ - }1}\)
-
bThe relative standard error (%RSE) was calculated as \(100 \times \left( {\frac{\text{SD}}{{{\text{Mean}}\;{\text{value}}}}} \right)\) from the non-parametric bootstrap results (n = 1000). The 95 % confidence interval (95 % CI) is presented as the 2.5–97.5 percentiles of the bootstrap estimates
