Parameter

Population estimate^{a}
(%RSE)^{b}

95 % CI^{b}

IIV (%CV)^{a}
(%RSE)^{b}

95 % CI^{b}


F_{IM}

1 fixed

–

–

–

F_{PO}

0.844 (8.4)

0.682–0.951

287 (49.1)

76.5–1038

DUR_{IM} (h)

0.689 (6.2)

0.621–0.784

–

–

k_{a,PO} (h^{−1})

4.15 (44.5)

1.95–9.73

232 (49.7)

39.9–574

CL (l/h)

10.7 (16.9)

7.35–14.7

81.8 (69.7)

24.4–164

V_{C} (l)

45.5 (8.5)

36.7–51.5

–

–

Q (l/h)

10.3 (36.8)

4.80–20.1

77.4 (44.0)

21.1–105

V_{P} (l)

11.3 (42.7)

5.01–29.0

428 (46.5)

112–2351

σ

0.376 (7.8)

0.316–0.436

–

–


F
_{
IM
} bioavailability after intramuscular administration, F
_{
PO
} relative bioavailability after oral syrup administration, DUR
_{
IM
} duration of zeroorder absorption after intramuscular administration, k
_{
a,PO
} absorption rate constant after oral syrup administration, CL apparent elimination clearance, V
_{
C
} apparent volume of distribution of the central compartment, Q intercompartment clearance, V
_{
P
} apparent volume of distribution of the peripheral compartment, σ variance of the residual variability

^{a}Population mean values and interindividual variability (IIV) estimated by NONMEM. The coefficient of variation (% CV) for IIV was calculated as \(100 \times \sqrt {\exp ({\text{estimate}}){  }1}\)

^{b}The relative standard error (%RSE) was calculated as \(100 \times \left( {\frac{\text{SD}}{{{\text{Mean}}\;{\text{value}}}}} \right)\) from the nonparametric bootstrap results (n = 1000). The 95 % confidence interval (95 % CI) is presented as the 2.5–97.5 percentiles of the bootstrap estimates